植物化学物质作为癌症风险的调节剂。

Phytochemicals as modulators of cancer risk.

作者信息

Bradlow H L, Telang N T, Sepkovic D W, Osborne M P

机构信息

Strang Cancer Research Laboratory, New York, NY 10021, USA.

出版信息

Adv Exp Med Biol. 1999;472:207-21. doi: 10.1007/978-1-4757-3230-6_18.

DOI:10.1007/978-1-4757-3230-6_18

PMID:10736628

Abstract

These results, describing antitumor activity of some of the phytochemicals that have been actively studied, suggest that dietary changes could play a role in decreasing the incidence of a variety of tumors. 13C and the other compounds discussed may well be only prototypes for other as yet unexplored phytochemicals present in the diet. There have been no attempts to explore the possibilities of synergistic action among the various phytochemicals, 13C, limonene, curcumin, epigallocatechin gallate, sulforaphene, or genistein. Mixtures of these compounds might well show potency at lower doses for each of the compounds and show even greater promise than that already demonstrated.

摘要

这些结果描述了一些已被积极研究的植物化学物质的抗肿瘤活性，表明饮食变化可能在降低多种肿瘤的发病率方面发挥作用。13C以及所讨论的其他化合物很可能只是饮食中其他尚未探索的植物化学物质的原型。目前尚未尝试探究各种植物化学物质、13C、柠檬烯、姜黄素、表没食子儿茶素没食子酸酯、萝卜硫素或染料木黄酮之间协同作用的可能性。这些化合物的混合物很可能在较低剂量下对每种化合物都显示出效力，并且比已证明的更具前景。