Torres-Sánchez L, López-Carrillo L, López-Cervantes M, Rueda-Neria C, Wolff M S
Center for Research on Health Services, National Institute of Public Health, Mexico, CP 62508, Cuernavaca, Morelos, Mexico.
Nutr Cancer. 2000;37(2):134-9. doi: 10.1207/S15327914NC372_3.
We analyzed the intake of selected foods that contain phytoestrogens in relation to breast cancer (BC) risk using data from a hospital-based case-control study performed in Mexico City from 1994 to 1995. A total of 198 women with BC, aged 21-79 years, were individually age matched to an identical number of women with no breast disease. By a direct interview, information on socioeconomic characteristics and diet was obtained. A semiquantitative questionnaire was used to estimate the frequency of consumption of 95 foods. The effect of selected foods that contain phytoestrogens on BC risk was estimated using logistic regression models. The adjusted odds ratio for the consumption of more than one slice of onion per day and BC was 0.27 (95% confidence interval = 0.16-0.47), with a statistically significant trend (p < 0.001). This protective effect remained after adjustment for known risk factors of BC. Among premenopausal women, there was also a protective and significant effect due to the intake of lettuce and spinach and nonsignificant protective effects for the consumption of apples and herbal tea. Additional studies aimed at evaluating the potential protective effect of particular phytoestrogens on BC risk are needed.
我们利用1994年至1995年在墨西哥城开展的一项基于医院的病例对照研究数据，分析了摄入含有植物雌激素的特定食物与乳腺癌（BC）风险之间的关系。共有198名年龄在21至79岁之间的乳腺癌女性患者，按照年龄分别与相同数量的无乳腺疾病女性进行匹配。通过直接访谈，获取了社会经济特征和饮食方面的信息。采用半定量问卷来估计95种食物的消费频率。使用逻辑回归模型估计了摄入含有植物雌激素的特定食物对乳腺癌风险的影响。每天食用超过一片洋葱与乳腺癌的校正比值比为0.27（95%置信区间 = 0.16 - 0.47），具有统计学显著趋势（p < 0.001）。在对已知的乳腺癌风险因素进行校正后，这种保护作用依然存在。在绝经前女性中，摄入生菜和菠菜也有显著的保护作用，而食用苹果和花草茶的保护作用不显著。需要开展更多研究以评估特定植物雌激素对乳腺癌风险的潜在保护作用。
