Charton-Bain M C, Lelong B, Bouabdallah R, Dubus P, Merlio J P, Hassoun J, Xerri L
Service d'Anatomie Pathologique, Institut Paoli-Calmettes, Marseille, France.
Ann Pathol. 2000 Mar;20(2):137-41.
We report a case of a 50-year-old man with chronic viral hepatitis B presenting with a primary hepatic lymphoma of mucosa-associated lymphoid tissue, revealed clinically by a pedicular nodal mass. The liver biopsy showed an active chronic hepatitis and a dense portal lymphoid infiltrate with centrocyte-like cells inducing typical biliary lympho-epithelial lesions. The lymph-node biopsy revealed a marginal zone lymphoma pattern. A monoclonal rearrangement of the immunoglobulin heavy chain gene was detected in the lymph node by polymerase chain reaction. This case of primary hepatic mucosa-associated lymphoid tissue lymphoma confirms that the liver also contains mucosa-associated lymphoid tissue, in which low grade lymphoma can arise.
我们报告一例50岁慢性乙型病毒性肝炎男性患者，其表现为黏膜相关淋巴组织原发性肝淋巴瘤，临床上通过蒂状淋巴结肿块得以揭示。肝脏活检显示为活动性慢性肝炎以及伴有中心细胞样细胞的密集门脉淋巴浸润，引发典型的胆管淋巴上皮病变。淋巴结活检显示为边缘区淋巴瘤模式。通过聚合酶链反应在淋巴结中检测到免疫球蛋白重链基因的单克隆重排。这例原发性肝黏膜相关淋巴组织淋巴瘤病例证实肝脏也含有黏膜相关淋巴组织，其中可发生低度淋巴瘤。
