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严重精神疾病日常功能损害的人口统计学、临床及神经认知相关性

Demographic, clinical, and neurocognitive correlates of everyday functional impairment in severe mental illness.

作者信息

Schretlen D, Jayaram G, Maki P, Park K, Abebe S, DiCarlo M

机构信息

Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

出版信息

J Abnorm Psychol. 2000 Feb;109(1):134-8.

Abstract

Although cognitive deficits often accompany severe mental illness, their implications for everyday functioning remain poorly understood. In this study, an occupational therapist (OT) rated the everyday functioning of 105 adult psychiatric patients. Using demographic, clinical, and cognitive variables, the authors tested alternative models to account for the observed variability in OT ratings. Although age, education, and the presence of schizophrenia each contributed to a model that accounted for 27% of the variation in functional independence, adding terms for auditory divided attention and verbal learning increased the proportion of explained variance to 45% and decreased the beta weights for age and education--but not schizophrenia--to nonsignificant levels. These findings demonstrate the relevance of cognitive performance to everyday functioning in severe mental illness. They are discussed with respect to hypothesized determinants of psychiatric disability.

摘要

尽管认知缺陷常伴随严重精神疾病出现,但其对日常功能的影响仍知之甚少。在本研究中,一名职业治疗师(OT)对105名成年精神病患者的日常功能进行了评估。作者利用人口统计学、临床和认知变量,测试了不同模型以解释OT评分中观察到的变异性。尽管年龄、教育程度和精神分裂症的存在各自对一个解释了功能独立性变异27%的模型有贡献,但加入听觉分散注意力和言语学习的变量后,可解释方差的比例增加到了45%,且年龄和教育程度(而非精神分裂症)的β权重降至不显著水平。这些发现证明了认知表现与严重精神疾病日常功能的相关性。文中还就精神病残疾的假定决定因素对这些发现进行了讨论。

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