De Groot C J, Oepkes D, Egberts J, Kanhai H H
Department of Obstetrics, Gynecology and Reproductive Sciences, Leiden University Medical Center, Leiden, The Netherlands.
Early Hum Dev. 2000 Mar;57(3):205-9. doi: 10.1016/s0378-3782(99)00063-8.
A fetus with signs of hydrops is at high risk of intrauterine death. The pathophysiology of hydrops fetalis is still unclear. We found decreased concentrations of cyclic guanosine monophosphate in fetal plasma of alloimmunized pregnancies complicated by hydrops fetalis, which might suggest reduced nitric oxide production due to injury of fetal vascular endothelial cells.
