von Schmiedeberg S, Rönnau A C, Schuppe H C, Specker C, Ruzicka T, Lehmann P
Hautklinik, Heinrich-Heine-Universität Düsseldorf.
Hautarzt. 2000 Feb;51(2):82-5. doi: 10.1007/s001050050017.
Antimalarials represent the first line in treatment of cutaneous lupus erythematosus (LE). However, some patients show no improvement on monotherapy with chloroquine or hydroxychloroquine. A 30-year-old female patient had treatment-resistant cutaneous LE exhibiting features of both LE tumidus and subacute cutaneous LE. Previously, the patient had been unsuccessfully treated with chloroquine, hydroxychloroquine, dapsone, and azathioprine, each in combination with variable doses of prednisolone. However, the LE lesions increased during these therapeutic regimens. A combination of chloroquine and mepacrine therapy led to improvement and then total clearing after 4 months of treatment.
抗疟药是治疗皮肤型红斑狼疮（LE）的一线用药。然而，一些患者单用氯喹或羟氯喹治疗并无改善。一名30岁女性患者患有对治疗抵抗的皮肤型LE，具有肿胀性LE和亚急性皮肤型LE的特征。该患者此前分别接受过氯喹、羟氯喹、氨苯砜和硫唑嘌呤治疗，每种药物均联合不同剂量的泼尼松龙，但均未成功。然而，在这些治疗方案期间，LE皮损仍有增加。氯喹和米帕林联合治疗使病情得到改善，治疗4个月后皮损完全消退。
