Corpet F, Gouzy J, Kahn D
Laboratoire de Génétique Cellulaire, Centre INRA de Toulouse, Castanet, France.
Bioinformatics. 1999 Dec;15(12):1020-7. doi: 10.1093/bioinformatics/15.12.1020.
Multiple alignments of protein sequences are the basis of structural and functional analysis of protein families. It is however difficult even for an expert biologist to comprehend an alignment of more than 50 to 100 homologous sequences.
This paper presents a browser for the analysis of multiple alignments of large numbers of protein sequences. Phylogenetic trees and consensus sequences are computed and used to summarise the alignments; these data are stored in a structure called Rich Family Description. Summary alignments and trees are displayed in HTML pages and can be developed or reduced by the user. This browser is used to display the ProDom domain families on the Web. Its zooming facilities allow extracting information from alignments of more than 1000 homologous sequences.
蛋白质序列的多序列比对是蛋白质家族结构和功能分析的基础。然而，即使是专业的生物学家也很难理解50到100条以上同源序列的比对结果。
本文提出了一种用于分析大量蛋白质序列多序列比对的浏览器。计算系统发育树和共有序列并用于总结比对结果；这些数据存储在一种称为丰富家族描述的结构中。总结比对结果和树状图显示在HTML页面中，用户可以对其进行展开或简化。此浏览器用于在网络上显示ProDom结构域家族。其缩放功能允许从1000多条同源序列的比对中提取信息。
