蛋白质结构域家族的ProDom数据库的近期改进。
Recent improvements of the ProDom database of protein domain families.
作者信息
Corpet F, Gouzy J, Kahn D
机构信息
Laboratoire de Génétique Cellulaire, INRA, BP27, F-31326 Castanet-Tolosan cedex, France.
出版信息
Nucleic Acids Res. 1999 Jan 1;27(1):263-7. doi: 10.1093/nar/27.1.263.
The ProDom database contains protein domain families generated from the SWISS-PROT database by automated sequence comparisons. The current version was built with a new improved procedure based on recursive PSI-BLAST homology searches. ProDom can be searched on the World Wide Web to study domain arrangements within either known families or new proteins, with the help of a user-friendly graphical interface (http://www.toulouse.inra.fr/prodom.html). Recent improvements to the ProDom server include: ProDom queries under the SRS Sequence Retrieval System; links to the PredictProtein server; phylogenetic trees and condensed multiple alignments for a better representation of large domain families, with zooming in and out capabilities. In addition, a similar server was set up to display the outcome of whole genome domain analysis as applied to 17 completed microbial genomes (http://www.toulouse.inra.fr/prodomCG.html ).
ProDom数据库包含通过自动序列比较从SWISS-PROT数据库生成的蛋白质结构域家族。当前版本是基于递归PSI-BLAST同源性搜索的新改进程序构建的。借助用户友好的图形界面（http://www.toulouse.inra.fr/prodom.html），可以在万维网上搜索ProDom，以研究已知家族或新蛋白质中的结构域排列。ProDom服务器的近期改进包括：在SRS序列检索系统下进行ProDom查询；与PredictProtein服务器的链接；系统发育树和压缩的多序列比对，以便更好地呈现大型结构域家族，并具备放大和缩小功能。此外，还设置了一个类似的服务器来展示应用于17个已完成的微生物基因组的全基因组结构域分析结果（http://www.toulouse.inra.fr/prodomCG.html ）。
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