Nayler S J, Allard U, Taylor L, Cooper K
Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa.
Mol Pathol. 1999 Dec;52(6):345-8. doi: 10.1136/mp.52.6.345.
Bacillary angiomatosis is a rare pseudoneoplastic angioproliferative lesion occurring in patients with AIDS. This condition has been associated with Bartonella henselae and Bartonella quintana infections. Human herpesvirus 8 (HHV-8) is thought to be the causative agent of Kaposi's sarcoma, a vasoproliferative neoplasm, also commonly found in patients with AIDS. The presence of HHV-8 in a cohort of patients with bacillary angiomatosis was investigated.
Eight cutaneous cases of biopsy confirmed bacillary angiomatosis were assessed for HHV-8 using standard solution phase polymerase chain reaction (PCR).
No case of bacillary angiomatosis harboured HHV-8 DNA.
HHV-8 was not demonstrated in the lesions of bacillary angiomatosis and therefore does not appear to play a role in the pathogenesis of this pseudoneoplastic angioproliferative disorder. This finding might be useful in the distinction of bacillary angiomatosis from Kaposi's sarcoma, because lesions from patients with Kaposi's sarcoma almost always contains HHV-8 DNA.
杆菌性血管瘤病是一种发生于艾滋病患者的罕见假肿瘤性血管增殖性病变。这种疾病与汉赛巴尔通体和五日热巴尔通体感染有关。人疱疹病毒8型（HHV - 8）被认为是卡波西肉瘤的病原体，卡波西肉瘤是一种血管增殖性肿瘤，也常见于艾滋病患者。本研究调查了一组杆菌性血管瘤病患者中HHV - 8的存在情况。
采用标准液相聚合酶链反应（PCR）对8例经活检确诊的皮肤杆菌性血管瘤病病例进行HHV - 8检测。
所有杆菌性血管瘤病病例均未检测到HHV - 8 DNA。
在杆菌性血管瘤病病变中未检测到HHV - 8，因此它似乎在这种假肿瘤性血管增殖性疾病的发病机制中不起作用。这一发现可能有助于杆菌性血管瘤病与卡波西肉瘤的鉴别，因为卡波西肉瘤患者的病变几乎总是含有HHV - 8 DNA。
