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Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring.

作者信息

Flier J S, Harris M, Hollenberg A N

机构信息

Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

出版信息

J Clin Invest. 2000 Apr;105(7):859-61. doi: 10.1172/JCI9725.

DOI:10.1172/JCI9725
PMID:10749565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC377492/
Abstract
摘要

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本文引用的文献

1
The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin.中枢黑皮质素系统影响下丘脑 - 垂体 - 甲状腺轴，并可能介导瘦素的作用。
J Clin Invest. 2000 Apr;105(7):1005-11. doi: 10.1172/JCI8857.
2
alpha-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression.α-黑素细胞刺激素存在于支配下丘脑室旁核中促甲状腺激素释放激素合成神经元的神经末梢中，并可防止禁食诱导的促甲状腺激素释放激素基因表达的抑制。
J Neurosci. 2000 Feb 15;20(4):1550-8. doi: 10.1523/JNEUROSCI.20-04-01550.2000.
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From lesions to leptin: hypothalamic control of food intake and body weight.从病变到瘦素：下丘脑对食物摄入和体重的控制
Neuron. 1999 Feb;22(2):221-32. doi: 10.1016/s0896-6273(00)81084-3.
4
Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus.弓状核消融可防止禁食诱导的下丘脑室旁核中促甲状腺激素释放激素原（ProTRH）mRNA表达受抑制。
Neuroendocrinology. 1998 Aug;68(2):89-97. doi: 10.1159/000054354.
5
Clinical review 94: What's in a name? In search of leptin's physiologic role.临床综述94：名字有何含义？探寻瘦素的生理作用。
J Clin Endocrinol Metab. 1998 May;83(5):1407-13. doi: 10.1210/jcem.83.5.4779.
6
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.人类瘦素受体基因的突变会导致肥胖和垂体功能障碍。
Nature. 1998 Mar 26;392(6674):398-401. doi: 10.1038/32911.
7
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.刺鼠相关蛋白在体外和体内对中枢黑皮质素受体的拮抗作用。
Science. 1997 Oct 3;278(5335):135-8. doi: 10.1126/science.278.5335.135.
8
Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.与刺鼠相关的一种新基因ART在下丘脑的表达在肥胖和糖尿病突变小鼠中上调。
Genes Dev. 1997 Mar 1;11(5):593-602. doi: 10.1101/gad.11.5.593.
9
Targeted disruption of the melanocortin-4 receptor results in obesity in mice.黑皮质素-4受体的靶向破坏导致小鼠肥胖。
Cell. 1997 Jan 10;88(1):131-41. doi: 10.1016/s0092-8674(00)81865-6.
10
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome.黑皮质素能神经元在进食及刺鼠肥胖综合征中的作用。
Nature. 1997 Jan 9;385(6612):165-8. doi: 10.1038/385165a0.