Heidenreich P, Oberdorfer M, Hör G
Nuklearmedizin. 1979 Feb;18(1):19-25.
Error and reproducibility of the total and divided renal clearance determination was investigated, using a partially shielded whole-body counter. The error of the total renal clearance determination using ortho-131I-hippuran (OIH) depends primarily on the downslope of the whole-body curve, i.e. on renal function. The error is as low as +/- 6% for clearance values of more than 100 ml/min and increases slowly with clearance values decreasing about 35 ml/min. The error of clearance values below 25 ml/min is higher than 50%. The error of the divided renal clearance using OIH is the same as the error of the total renal clearance. The reproducibility of the total OIH-clearance in single clearance periods was found to be +/- 6% and in repeated determinations +/- 12% (r = 0.97). The reproducibility of the divided renal OIH-clearance with scintillation probes showed an average deviation from the mean of +/- 10% (r = 0.87). The substitution of the scintillation probes by a scintillation camera and the use of regions of interest should diminish this error considerably. The results were compared with literature data on standard PAH- and inulin clearances.
使用部分屏蔽的全身计数器研究了总肾清除率和分侧肾清除率测定的误差及可重复性。使用邻碘马尿酸（OIH）测定总肾清除率的误差主要取决于全身曲线的下降斜率，即肾功能。清除率值超过100 ml/min时，误差低至±6%，且随着清除率值降至约35 ml/min，误差缓慢增加。清除率值低于25 ml/min时，误差高于50%。使用OIH测定分侧肾清除率的误差与总肾清除率的误差相同。发现单次清除期总OIH清除率的可重复性为±6%，重复测定时为±12%（r = 0.97）。使用闪烁探头测定分侧肾OIH清除率的可重复性显示，与平均值的平均偏差为±10%（r = 0.87）。用闪烁相机替代闪烁探头并使用感兴趣区应可大幅减少此误差。将结果与关于标准对氨基马尿酸（PAH）清除率和菊粉清除率的文献数据进行了比较。
