MacKay R J
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, USA.
Vet Clin North Am Equine Pract. 2000 Apr;16(1):15-27, v. doi: 10.1016/s0749-0739(17)30116-5.
After inflammation is initiated by detection of antigen, plasma components and activated leukocytes are concentrated at the inflammatory site. Cellular and chemical effectors of inflammation are focused on the offending antigen, usually resulting in its destruction and elimination. Activation of endogenous counter-regulatory systems damps down the inflammatory process and is the first stage of repair. In addition to local effects, the inflammatory focus may initiate a continuum of systemic acute phase responses ranging from the systemic inflammatory response syndrome (SIRS) to generalized immunosuppression.
在通过检测抗原引发炎症后，血浆成分和活化的白细胞会聚集在炎症部位。炎症的细胞和化学效应器集中作用于引发炎症的抗原，通常会导致其被破坏和清除。内源性反调节系统的激活会抑制炎症过程，这是修复的第一阶段。除了局部影响外，炎症病灶可能引发一系列全身性急性期反应，范围从全身炎症反应综合征（SIRS）到全身性免疫抑制。
