Lackey B R, Gray S L, Henricks D M
Endocrine Physiology Laboratory, Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA.
Growth Horm IGF Res. 2000 Feb;10(1):1-13. doi: 10.1054/ghir.1999.0129.
Insulin-like growth factors (IGF) are pleiotrophic polypeptides affecting all aspects of growth and development. The IGF system, including ligands, receptors, binding proteins and proteases is also involved in pathophysiological conditions, such as cancer and degenerative conditions. In this review, the actions and interactions of the IGF system as it relates to Alzheimer's disease will be investigated.
胰岛素样生长因子（IGF）是影响生长和发育各个方面的多效性多肽。IGF系统，包括配体、受体、结合蛋白和蛋白酶，也参与病理生理状况，如癌症和退行性疾病。在本综述中，将研究IGF系统与阿尔茨海默病相关的作用和相互作用。
