SWI/SNF复合物对启动子的靶向作用及染色质重塑
Promoter targeting and chromatin remodeling by the SWI/SNF complex.
作者信息
Peterson C L, Workman J L
机构信息
Department of Biochemistry and Molecular Biology, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA.
出版信息
Curr Opin Genet Dev. 2000 Apr;10(2):187-92. doi: 10.1016/s0959-437x(00)00068-x.
The SWI/SNF complex is a 2 MDa multi-subunit DNA-dependent ATPase that contributes to the regulation of gene transcription by altering chromatin structure. Recent studies have revealed that the SWI/SNF complex is targeted to promoters via direct interactions with transcription activators and have provided insights into mechanisms by which the complex alters nucleosome structure and contributes to the remodeling of chromatin.
SWI/SNF复合物是一种2兆道尔顿的多亚基DNA依赖性ATP酶，它通过改变染色质结构来促进基因转录的调控。最近的研究表明，SWI/SNF复合物通过与转录激活因子的直接相互作用靶向启动子，并深入了解了该复合物改变核小体结构和促进染色质重塑的机制。
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