Pouget A, Driver J
Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA.
Curr Opin Neurobiol. 2000 Apr;10(2):242-9. doi: 10.1016/s0959-4388(00)00077-5.
Neuropsychological findings on the human neglect syndrome after parietal damage may relate to the physiological properties of single cells that have been studied in monkey parietal cortex and in related brain areas. Human neglect may reflect partial loss or dysfunction of similar cell populations, producing a pathological gradient in the numbers of cells representing particular lateral positions in space, for particular functions. This can explain the graded deficits seen in patients. We relate the patient deficits to cellular properties for several current issues: spatial frames-of-reference; multimodal integration; effective treatments for neglect; motor components to parietal function; and residual unconscious processing. A neural perspective may resolve traditional debates in the neglect literature and outline directions for future research.
关于人类顶叶损伤后忽视综合征的神经心理学研究结果，可能与在猴顶叶皮层及相关脑区所研究的单个细胞的生理特性有关。人类忽视可能反映了类似细胞群的部分丧失或功能障碍，从而在代表空间中特定横向位置的细胞数量上，针对特定功能产生一种病理梯度。这可以解释在患者身上看到的分级缺陷。我们将患者的缺陷与细胞特性联系起来，以探讨几个当前的问题：空间参照系；多模态整合；忽视的有效治疗方法；顶叶功能的运动成分；以及残留的无意识加工。神经学视角可能会解决忽视文献中的传统争论，并为未来研究指明方向。
