Jospe E S, Peppercorn M A
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Mass., USA.
Dig Dis. 1999;17(4):201-7. doi: 10.1159/000016937.
Inflammatory bowel disease often occurs during peak reproductive years. Rates of conception, pregnancy outcome and disease course during pregnancy should be discussed prior to attempted conception. The majority of patients whose disease is well controlled prior to pregnancy should expect a fertility rate comparable to the general population, and an uncomplicated pregnancy with a favorable outcome. The disease should continue to be pharmacologically or surgically controlled as necesssary during pregnancy; the majority of drug options available to pregnant patients being without detriment to the fetus. No predictable inheritance pattern has been established and, at this time, there is no ability to screen prenatally.
炎症性肠病常发生在生育高峰期。在尝试受孕前,应讨论受孕率、妊娠结局及孕期疾病进程。大多数在怀孕前疾病得到良好控制的患者,其生育率应与普通人群相当,且妊娠过程顺利、结局良好。孕期应根据需要继续通过药物或手术控制疾病;大多数可供孕妇使用的药物对胎儿无害。目前尚未确立可预测的遗传模式,且此时无法进行产前筛查。