Wutzler P, Sauerbrei A, Klöcking R, Burkhardt J, Schacke M, Thust R, Fleischer W, Reimer K
Institute for Antiviral Chemotherapy, Friedrich Schiller University, Jena, Germany.
Ophthalmic Res. 2000 Mar-Jun;32(2-3):118-25. doi: 10.1159/000055600.
Povidone-iodine (PVP-I) is a broad-spectrum microbicide with in vitro activity against bacteria, viruses, fungi and protozoans. A 5% solution of PVP-I proved to be highly effective in ophthalmic surgery for the prophylaxis of endophthalmitis. For the antiseptic treatment of eye infections a novel application form of PVP-I has been developed by using a PVP-I liposome complex which demonstrated an excellent antimicrobial efficacy. In this study it could be shown that the novel liposomal formulations containing 2.5 or 5% PVP-I were as active as the aqueous solution against herpes simplex virus type 1, adenovirus type 8, coxsackievirus A9 and Chlamydia trachomatis in cell culture referring to equal PVP-I concentrations. Long-term cytotoxicity experiments demonstrated a moderate cytotoxicity for both formulations with a better tolerability of the liposomal PVP-I formulation compared with the aqueous solution. There is no evidence for a genotoxic activity of these agents.
聚维酮碘（PVP - I）是一种广谱杀菌剂，在体外对细菌、病毒、真菌和原生动物具有活性。5%的聚维酮碘溶液在眼科手术中被证明对预防眼内炎非常有效。为了对眼部感染进行抗菌治疗，通过使用聚维酮碘脂质体复合物开发了一种新型的聚维酮碘应用形式，该复合物显示出优异的抗菌效果。在本研究中可以表明，在细胞培养中，对于相同的聚维酮碘浓度，含有2.5%或5%聚维酮碘的新型脂质体制剂与水溶液对1型单纯疱疹病毒、8型腺病毒、柯萨奇病毒A9和沙眼衣原体的活性相同。长期细胞毒性实验表明，两种制剂都具有中等细胞毒性，与水溶液相比，脂质体聚维酮碘制剂的耐受性更好。没有证据表明这些制剂具有遗传毒性活性。
