Thomas D, Orfila F, Bissac E
Pathol Biol (Paris). 1984 Jun;32(5 Pt 2):544-6.
We compared the activity of different antiseptics (chlorhexidine, picloxidine dichlorhydrate, povidone-iodine, and noxythiolin) on Chlamydia trachomatis using two techniques. In the first, an antigenic preparation obtained from a Chlamydia trachomatis-infected cell culture was used. Different times of contact and different concentrations were studied. The antigen-antiseptic mixture was inoculated on healthy cell cultures and infected cells were counted 48 hours later. In the second technique, previously infected cells were incubated with antiseptics at different concentrations for 48 hours. Results are given as a percentage of infected cells. Chlorhexidine and picloxidine dichlorhydrate have a rapid action on Chlamydia trachomatis. Noxythiolin requires a longer period (2 hours) to be active. Povidone-iodine exhibits no activity on Chlamydia trachomatis.
我们使用两种技术比较了不同防腐剂（洗必泰、二盐酸吡氯腙、聚维酮碘和硝噻唑啉）对沙眼衣原体的活性。第一种方法是使用从沙眼衣原体感染的细胞培养物中获得的抗原制剂。研究了不同的接触时间和不同的浓度。将抗原 - 防腐剂混合物接种到健康细胞培养物上，48小时后对感染细胞进行计数。在第二种技术中，将先前感染的细胞与不同浓度的防腐剂孵育48小时。结果以感染细胞的百分比表示。洗必泰和二盐酸吡氯腙对沙眼衣原体有快速作用。硝噻唑啉需要较长时间（2小时）才能发挥作用。聚维酮碘对沙眼衣原体无活性。
