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Oligomeric building block approach to the synthesis of diastereomerically pure pentathymidine 3',5'-methanephosphonates.

作者信息

Pyzowski J, Wozniak L A, Stec W J

机构信息

Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lódz, Poland.

出版信息

Org Lett. 2000 Mar 23;2(6):771-3. doi: 10.1021/ol991376o.

DOI:10.1021/ol991376o
PMID:10754680
Abstract

[formula: see text] A method for a large-scale synthesis of stereodefined oligo(nucleoside 3',5'-methanephosphonates) has been developed, based on transient 3'-O protection, which allows for the conversion of the protecting chirally defined methanephosphonanilidate group, located at the 3' end of a stereoregular oligomer, into diastereomerically pure "oligomeric building blocks" for stereospecific coupling with the 5'-OH group of another oligonucleotide.

摘要

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