Scoular A, Kinghorn G
Department of Genitourinary Medicine and Sexual Health, Glasgow Royal Infirmary University NHS Trust.
Sex Transm Infect. 1999 Dec;75(6):403-5. doi: 10.1136/sti.75.6.403.
To investigate the current use of diagnostic methods for genital herpes simplex virus (HSV) infection, to determine how information from these tests influences clinical practice, and to identify areas for future guideline development within genitourinary medicine (GUM) clinics in the United Kingdom.
National survey of 173 consultants in UK GUM clinics.
Completed questionnaires were returned by 146 (84%) consultants. Cell culture was the first line diagnostic method for 133 (91%) respondents, the remaining 13 (9%) used antigen detection tests. Typing of isolates (HSV-1 or HSV-2) was available in their local laboratory to 109 (75%) clinicians; however, less than two thirds routinely pass this information on to their patients. Although 74 (51%) respondents had access to serological diagnosis, the majority of methods described were non-specific; only three (2%) had access to type specific tests. Only 81 (56%) respondents frequently (> 90% of the time) recommend notification of recent sexual partners of genital herpes patients.
While access to culture based diagnosis is widespread, type specific serology has limited availability. Information on typing of isolates as HSV-1 or 2, although available in three quarters of centres, is underutilized in counselling patients. As HSV type influences both clinical and subclinical reactivation rates and may also affect probability of transmission, this is an important omission. Future guidelines need to address the optimal use of viral typing and new diagnostic tests to optimise health gain; there is also a need for evidence based recommendations about partner notification in genital herpes.
调查目前生殖器单纯疱疹病毒(HSV)感染诊断方法的使用情况,确定这些检测所得信息如何影响临床实践,并找出英国泌尿生殖医学(GUM)诊所未来制定指南的方向。
对英国173名GUM诊所的顾问进行全国性调查。
146名(84%)顾问返回了完整问卷。133名(91%)受访者将细胞培养作为一线诊断方法,其余13名(9%)使用抗原检测试验。109名(75%)临床医生所在的当地实验室可对分离株进行分型(HSV-1或HSV-2);然而,不到三分之二的医生会将此信息常规告知患者。虽然74名(51%)受访者可以进行血清学诊断,但所描述的大多数方法都不具有特异性;只有3名(2%)可以进行分型特异性检测。只有81名(56%)受访者经常(>90%的时间)建议对生殖器疱疹患者近期的性伴侣进行通报。
虽然基于培养的诊断方法应用广泛,但分型特异性血清学检测的可用性有限。关于分离株为HSV-1或2型的分型信息,虽然在四分之三的中心都有,但在为患者提供咨询时未得到充分利用。由于HSV类型会影响临床和亚临床复发率,也可能影响传播概率,这是一个重要的遗漏。未来的指南需要解决病毒分型和新诊断检测的最佳使用问题,以优化健康收益;还需要基于证据的关于生殖器疱疹患者性伴侣通报的建议。