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1
British Co-operative Clinical Group national survey on diagnostic issues surrounding genital herpes. MSSVD Special Interest Group on Genital Herpes and the British Co-operative Clinical Group.英国合作临床小组关于生殖器疱疹相关诊断问题的全国性调查。性传播感染学会生殖器疱疹特别兴趣小组与英国合作临床小组。
Sex Transm Infect. 1999 Dec;75(6):403-5. doi: 10.1136/sti.75.6.403.
2
First episodes of genital herpes in a Swedish STD population: a study of epidemiology and transmission by the use of herpes simplex virus (HSV) typing and specific serology.瑞典性传播疾病人群中生殖器疱疹的初发病例:一项利用单纯疱疹病毒(HSV)分型和特异性血清学对流行病学及传播情况的研究。
Sex Transm Infect. 2000 Jun;76(3):179-82. doi: 10.1136/sti.76.3.179.
3
National survey of diagnostic services for genital herpes.全国生殖器疱疹诊断服务调查。
Sex Transm Infect. 2005 Aug;81(4):316-7. doi: 10.1136/sti.2004.013110.
4
Current diagnostic techniques in genital herpes: their role in controlling the epidemic.生殖器疱疹的当前诊断技术:它们在控制疫情中的作用。
Clin Lab. 2000;46(11-12):591-607.
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Role of type-specific herpes simplex virus-1 and 2 serology as a diagnostic modality in patients with clinically suspected genital herpes: A comparative study in Indian population from a tertiary care hospital.特定型单纯疱疹病毒1型和2型血清学在临床疑似生殖器疱疹患者中作为诊断方法的作用:来自一家三级护理医院的印度人群的比较研究
Indian J Pathol Microbiol. 2016 Jul-Sep;59(3):318-21. doi: 10.4103/0377-4929.188104.
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Using the evidence base on genital herpes: optimising the use of diagnostic tests and information provision.利用关于生殖器疱疹的证据库:优化诊断测试的使用和信息提供。
Sex Transm Infect. 2002 Jun;78(3):160-5. doi: 10.1136/sti.78.3.160.
7
A comparison of PCR with virus isolation and direct antigen detection for diagnosis and typing of genital herpes.聚合酶链反应(PCR)与病毒分离及直接抗原检测用于生殖器疱疹诊断和分型的比较。
J Med Virol. 1998 Jun;55(2):177-83.
8
Using centralized laboratory data to monitor trends in herpes simplex virus type 1 and 2 infection in British Columbia and the changing etiology of genital herpes.利用集中化的实验室数据监测不列颠哥伦比亚省单纯疱疹病毒 1 型和 2 型感染的趋势以及生殖器疱疹病因的变化。
Can J Public Health. 2011 May-Jun;102(3):225-9. doi: 10.1007/BF03404902.
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[Laboratory diagnosis of genital herpes--direct immunofluorescence method].[生殖器疱疹的实验室诊断——直接免疫荧光法]
Ginekol Pol. 2013 Jul;84(7):615-9. doi: 10.17772/gp/1613.
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Management of recurrent genital herpes: a survey of UK genitourinary medicine clinics in 2003.复发性生殖器疱疹的管理:2003年英国性健康诊所调查
Int J STD AIDS. 2005 Nov;16(11):760-2. doi: 10.1258/095646205774763216.

引用本文的文献

1
Light microscopy, culture, molecular, and serologic methods for detection of herpes simplex virus.用于检测单纯疱疹病毒的光学显微镜检查、培养、分子和血清学方法。
J Clin Microbiol. 2014 Jan;52(1):2-8. doi: 10.1128/JCM.01966-13. Epub 2013 Oct 16.
2
National survey of diagnostic services for genital herpes.全国生殖器疱疹诊断服务调查。
Sex Transm Infect. 2005 Aug;81(4):316-7. doi: 10.1136/sti.2004.013110.
3
Diagnosis of genital herpes by real time PCR in routine clinical practice.在常规临床实践中通过实时聚合酶链反应诊断生殖器疱疹
Sex Transm Infect. 2004 Oct;80(5):406-10. doi: 10.1136/sti.2003.008201.
4
Using the evidence base on genital herpes: optimising the use of diagnostic tests and information provision.利用关于生殖器疱疹的证据库:优化诊断测试的使用和信息提供。
Sex Transm Infect. 2002 Jun;78(3):160-5. doi: 10.1136/sti.78.3.160.
5
Polymerase chain reaction for diagnosis of genital herpes in a genitourinary medicine clinic.在泌尿生殖医学诊所中用于诊断生殖器疱疹的聚合酶链反应
Sex Transm Infect. 2002 Feb;78(1):21-5. doi: 10.1136/sti.78.1.21.
6
Sorting out the new HSV type specific antibody tests.梳理新型单纯疱疹病毒(HSV)分型特异性抗体检测方法。
Sex Transm Infect. 2001 Aug;77(4):232-7. doi: 10.1136/sti.77.4.232.

本文引用的文献

1
Type-specific serological testing for herpes simplex infection.单纯疱疹感染的型特异性血清学检测。
Int J STD AIDS. 1998 Sep;9(9):497-500. doi: 10.1258/0956462981922674.
2
Patient attitudes to type specific serological tests in the diagnosis of genital herpes.患者对特定类型血清学检测在生殖器疱疹诊断中的态度。
Genitourin Med. 1997 Aug;73(4):259-62. doi: 10.1136/sti.73.4.259.
3
HSV type specific antibody tests: patients are ready, are clinicians?单纯疱疹病毒分型特异性抗体检测:患者已准备好,临床医生呢?
Genitourin Med. 1997 Aug;73(4):235-6. doi: 10.1136/sti.73.4.235.
4
Asymptomatic shedding of herpes simplex virus from the genital tract: uncertainty and its consequences for patient management. The Herpes Simplex Virus Advisory Panel.单纯疱疹病毒在生殖道的无症状排毒:不确定性及其对患者管理的影响。单纯疱疹病毒咨询小组。
Int J STD AIDS. 1996 Jul;7(4):229-32. doi: 10.1258/0956462961917799.
5
Recurrence rates in genital herpes after symptomatic first-episode infection.有症状的初发性生殖器疱疹感染后的复发率。
Ann Intern Med. 1994 Dec 1;121(11):847-54. doi: 10.7326/0003-4819-121-11-199412010-00004.
6
Antibody to herpes simplex virus type 2 as serological marker of sexual lifestyle in populations.2型单纯疱疹病毒抗体作为人群性生活方式的血清学标志物。
BMJ. 1994 Nov 19;309(6965):1325-9. doi: 10.1136/bmj.309.6965.1325.
7
Risk of recurrence after first episodes of genital herpes. Relation to HSV type and antibody response.生殖器疱疹首次发作后的复发风险。与单纯疱疹病毒类型及抗体反应的关系。
N Engl J Med. 1981 Aug 6;305(6):315-9. doi: 10.1056/NEJM198108063050604.
8
Frequency of acquisition of first-episode genital infection with herpes simplex virus from symptomatic and asymptomatic source contacts.从有症状和无症状传染源接触者处首次感染单纯疱疹病毒引起生殖器感染的频率。
Sex Transm Dis. 1985 Jan-Mar;12(1):33-9. doi: 10.1097/00007435-198501000-00007.
9
Development of clinically recognizable genital lesions among women previously identified as having "asymptomatic" herpes simplex virus type 2 infection.先前被认定为患有“无症状”2型单纯疱疹病毒感染的女性中出现临床可识别的生殖器病变。
Ann Intern Med. 1989 Jun 1;110(11):882-7. doi: 10.7326/0003-4819-110-11-882.

英国合作临床小组关于生殖器疱疹相关诊断问题的全国性调查。性传播感染学会生殖器疱疹特别兴趣小组与英国合作临床小组。

British Co-operative Clinical Group national survey on diagnostic issues surrounding genital herpes. MSSVD Special Interest Group on Genital Herpes and the British Co-operative Clinical Group.

作者信息

Scoular A, Kinghorn G

机构信息

Department of Genitourinary Medicine and Sexual Health, Glasgow Royal Infirmary University NHS Trust.

出版信息

Sex Transm Infect. 1999 Dec;75(6):403-5. doi: 10.1136/sti.75.6.403.

DOI:10.1136/sti.75.6.403
PMID:10754945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1758269/
Abstract

OBJECTIVES

To investigate the current use of diagnostic methods for genital herpes simplex virus (HSV) infection, to determine how information from these tests influences clinical practice, and to identify areas for future guideline development within genitourinary medicine (GUM) clinics in the United Kingdom.

METHODS

National survey of 173 consultants in UK GUM clinics.

RESULTS

Completed questionnaires were returned by 146 (84%) consultants. Cell culture was the first line diagnostic method for 133 (91%) respondents, the remaining 13 (9%) used antigen detection tests. Typing of isolates (HSV-1 or HSV-2) was available in their local laboratory to 109 (75%) clinicians; however, less than two thirds routinely pass this information on to their patients. Although 74 (51%) respondents had access to serological diagnosis, the majority of methods described were non-specific; only three (2%) had access to type specific tests. Only 81 (56%) respondents frequently (> 90% of the time) recommend notification of recent sexual partners of genital herpes patients.

CONCLUSIONS

While access to culture based diagnosis is widespread, type specific serology has limited availability. Information on typing of isolates as HSV-1 or 2, although available in three quarters of centres, is underutilized in counselling patients. As HSV type influences both clinical and subclinical reactivation rates and may also affect probability of transmission, this is an important omission. Future guidelines need to address the optimal use of viral typing and new diagnostic tests to optimise health gain; there is also a need for evidence based recommendations about partner notification in genital herpes.

摘要

目的

调查目前生殖器单纯疱疹病毒(HSV)感染诊断方法的使用情况,确定这些检测所得信息如何影响临床实践,并找出英国泌尿生殖医学(GUM)诊所未来制定指南的方向。

方法

对英国173名GUM诊所的顾问进行全国性调查。

结果

146名(84%)顾问返回了完整问卷。133名(91%)受访者将细胞培养作为一线诊断方法,其余13名(9%)使用抗原检测试验。109名(75%)临床医生所在的当地实验室可对分离株进行分型(HSV-1或HSV-2);然而,不到三分之二的医生会将此信息常规告知患者。虽然74名(51%)受访者可以进行血清学诊断,但所描述的大多数方法都不具有特异性;只有3名(2%)可以进行分型特异性检测。只有81名(56%)受访者经常(>90%的时间)建议对生殖器疱疹患者近期的性伴侣进行通报。

结论

虽然基于培养的诊断方法应用广泛,但分型特异性血清学检测的可用性有限。关于分离株为HSV-1或2型的分型信息,虽然在四分之三的中心都有,但在为患者提供咨询时未得到充分利用。由于HSV类型会影响临床和亚临床复发率,也可能影响传播概率,这是一个重要的遗漏。未来的指南需要解决病毒分型和新诊断检测的最佳使用问题,以优化健康收益;还需要基于证据的关于生殖器疱疹患者性伴侣通报的建议。