Marchewka Z, Kuźniar J, Długosz A
Department of Toxicology, Wrocław University of Medicine, Poland.
Int Urol Nephrol. 1999;31(5):727-34. doi: 10.1023/a:1007181126577.
Toxicity of cyclosporine (CsA), an immunosuppressive drug widely used in transplantation, to the transplanted kidney creates a serious side effect. Therefore, searching for sensitive indicators of nephrotoxic action is well worth the effort. In this work we describe the results of estimation of urine concentration of lysosomal enzymes widely present in the kidney: N-acetyl-beta-D-glucosaminidase (NAG), its isoenzyme NAG-B and beta-glucuronidase (beta-Gr). The studies were conducted in various periods after transplantation of kidneys, on patients under various treatments and receiving different doses of CsA. The results indicate a substantial dependence of the activity of NAG and NAG-B on CsA doses and the period after transplantation. The enzyme proved to be also a sensitive indicator of graft rejection. No such dependence was observed in the case of beta-Gr.
环孢素（CsA）是一种广泛用于移植的免疫抑制药物，它对移植肾的毒性会产生严重的副作用。因此，寻找肾毒性作用的敏感指标是非常值得的。在这项工作中，我们描述了对肾脏中广泛存在的溶酶体酶尿液浓度的估计结果：N-乙酰-β-D-氨基葡萄糖苷酶（NAG）、其同工酶NAG-B和β-葡萄糖醛酸酶（β-Gr）。研究在肾移植后的不同时期进行，针对接受不同治疗和不同剂量CsA的患者。结果表明，NAG和NAG-B的活性与CsA剂量以及移植后的时期有很大关系。该酶也被证明是移植排斥的敏感指标。而对于β-Gr则未观察到这种关系。
