Chow S S, Thorner P, Baumal R, Wilson D R
Transplantation. 1986 Feb;41(2):152-6. doi: 10.1097/00007890-198602000-00003.
To investigate the interaction of cyclosporine nephrotoxicity and renal ischemia, an animal model in rats with bilateral renal artery clamping was used. Rats given cyclosporine had a lower rate of recovery from ischemia. However, the percentages of reduction in glomerular filtration rate in vehicle and cyclosporine groups were the same in sham-operated or ischemically treated group. This suggests a superimposition of cyclosporine nephrotoxicity on the recovering kidneys rather than synergistic potentiation between ischemia and cyclosporine nephrotoxicity.
为研究环孢素肾毒性与肾缺血之间的相互作用，采用双侧肾动脉夹闭的大鼠动物模型。给予环孢素的大鼠缺血恢复率较低。然而，在假手术组或缺血治疗组中，溶剂对照组和环孢素组的肾小球滤过率降低百分比相同。这表明环孢素肾毒性叠加在正在恢复的肾脏上，而非缺血与环孢素肾毒性之间的协同增强作用。
