Añíbarro B, Seoane F J, Vila C, Lombardero M
Sección de Alergia, Hospital Severo Ochoa, Leganés, and ALK-Abelló, Madrid, Spain.
J Allergy Clin Immunol. 2000 Apr;105(4):834-6. doi: 10.1067/mai.2000.104547.
Eggs are among the foods most frequently causing allergy. Hen eggs are the most important. Those of other birds are of lesser significance.
We report an unusual case of food allergy after consumption of eggs from duck and goose in an adult patient without hen egg allergy.
Skin prick tests were performed with fresh white and yolk from eggs of duck and goose and egg white, egg yolk, ovalbumin, and ovomucoid from hen egg. Specific serum IgE was measured to hen egg proteins. SDS-PAGE and IgE immunoblotting were carried out with egg white extracts from hen, duck, and goose.
Skin tests were positive to egg whites from duck and goose. The skin tests and specific serum IgE were negative to hen egg proteins. Immunoblotting demonstrated the presence of specific IgE to a proteic band of molecular weight around 45 kd.
We report a patient with an IgE-mediated allergy to egg white from duck and goose without hen egg allergy. Ovalbumin seems to be the responsible protein. The antigenic determinant of this protein seems to be specific of order Anseriforme and it is not present in the ovalbumin of order Galliforme.
鸡蛋是最常引起过敏的食物之一。鸡蛋最为重要，其他鸟类的蛋重要性较低。
我们报告一例成年患者在食用鸭蛋和鹅蛋后出现食物过敏的罕见病例，该患者对鸡蛋不过敏。
用新鲜的鸭蛋和鹅蛋的蛋白与蛋黄以及鸡蛋的蛋清、蛋黄、卵清蛋白和卵类粘蛋白进行皮肤点刺试验。检测针对鸡蛋蛋白的特异性血清IgE。对鸡、鸭和鹅的蛋清提取物进行SDS-PAGE和IgE免疫印迹分析。
对鸭蛋和鹅蛋的蛋清皮肤试验呈阳性。对鸡蛋蛋白的皮肤试验和特异性血清IgE呈阴性。免疫印迹显示存在针对分子量约45kd的蛋白条带的特异性IgE。
我们报告了一例对鸭蛋和鹅蛋蛋清有IgE介导的过敏反应但对鸡蛋不过敏的患者。卵清蛋白似乎是致病蛋白。该蛋白的抗原决定簇似乎是雁形目特有的，而在鸡形目的卵清蛋白中不存在。
