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新生儿和小婴儿共同动脉干修复术后的再次干预

Reinterventions after repair of common arterial trunk in neonates and young infants.

作者信息

McElhinney D B, Rajasinghe H A, Mora B N, Reddy V M, Silverman N H, Hanley F L

机构信息

Division of Cardiothoracic Surgery, University of California, San Francisco, USA.

出版信息

J Am Coll Cardiol. 2000 Apr;35(5):1317-22. doi: 10.1016/s0735-1097(00)00551-9.

Abstract

OBJECTIVES

To determine rates of reintervention after repair of common arterial trunk in the neonatal and early infant periods.

BACKGROUND

With improving success in the early treatment of common arterial trunk, the need for reinterventional procedures in older children, adolescents and adults will become an increasingly widespread concern in the treatment of these patients.

METHODS

We reviewed our experience with 159 infants younger than four months of age who underwent complete primary repair of common arterial trunk at our institution from 1975 to 1998, with a focus on postoperative reinterventions.

RESULTS

Of 128 early survivors, 40 underwent early reinterventions for persistent mediastinal bleeding or other reasons. During a median follow-up of 98 months (range, 2 to 235 months), 121 reinterventions were performed in 81 patients. Actuarial freedom from reintervention was 50% at four years, and freedom from a second reintervention was 75% at 11 years. A total of 92 conduit reinterventions were performed in 75 patients, with a single reintervention in 61 patients, 2 reinterventions in 11 patients and 3 reinterventions in 3 patients. Freedom from a first conduit reintervention was 45% at five years. The only independent variable predictive of a longer time to first conduit replacement was use of an allograft conduit at the original repair (p = 0.05), despite the significantly younger age of patients receiving an allograft conduit (p < 0.001). Reintervention on the truncal valve was performed on 22 occasions in 19 patients, including 21 valve replacements in 18 patients and repair in 1, with a freedom from truncal valve reintervention of 83% at 10 years. Surgical (n = 29) or balloon (n = 12) reintervention for pulmonary artery stenosis was performed 41 times in 32 patients. Closure of a residual ventricular septal defect was required in 13 patients, all of whom underwent closure originally with a continuous suture technique. Eight of 16 late deaths were related to reintervention.

CONCLUSIONS

The burden of reintervention after repair of common arterial trunk in early infancy is high. Although conduit reintervention is inevitable, efforts should be made at the time of the initial repair to minimize factors leading to reintervention, including prevention of branch pulmonary artery stenosis and residual interventricular communications.

摘要

目的

确定新生儿期和婴儿早期共同动脉干修复术后再次干预的发生率。

背景

随着共同动脉干早期治疗成功率的提高,大龄儿童、青少年和成人再次干预手术的需求将成为这些患者治疗中日益普遍关注的问题。

方法

我们回顾了1975年至1998年在我院接受共同动脉干一期完全修复的159例4个月以下婴儿的经验,重点关注术后再次干预情况。

结果

128例早期存活者中,40例因持续性纵隔出血或其他原因接受了早期再次干预。在中位随访98个月(范围2至235个月)期间,81例患者共进行了121次再次干预。4年时无再次干预的精算生存率为50%,11年时无二次再次干预的生存率为75%。75例患者共进行了92次管道再次干预,其中61例患者进行了1次再次干预,11例患者进行了2次再次干预,3例患者进行了3次再次干预。5年时首次管道再次干预的无干预生存率为45%。预测首次管道置换时间较长的唯一独立变量是初次修复时使用同种异体管道(p = 0.05),尽管接受同种异体管道的患者年龄明显较小(p < 0.001)。19例患者进行了22次动脉干瓣膜再次干预,其中18例患者进行了21次瓣膜置换,1例患者进行了修复,10年时动脉干瓣膜再次干预的无干预生存率为83%。32例患者因肺动脉狭窄进行了41次手术(n = 29)或球囊(n = 12)再次干预。13例患者需要关闭残余室间隔缺损,所有患者最初均采用连续缝合技术进行关闭。16例晚期死亡中有8例与再次干预有关。

结论

婴儿早期共同动脉干修复术后再次干预的负担较高。尽管管道再次干预不可避免,但在初次修复时应努力减少导致再次干预的因素,包括预防分支肺动脉狭窄和残余室间交通。

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