Stelow E B, Johari V P, Smith S A, Crosson J T, Apple F S
Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, Minneapolis, MN 55415, USA.
Clin Chem. 2000 Apr;46(4):577-81.
Propofol, a central-acting sedative agent, has been implicated in the development of rhabdomyolysis in children. We describe two adults who developed rhabdomyolysis after receiving high rates of propofol infusion. Rhabdomyolysis of both skeletal and cardiac muscle was suggested in both patients by marked increases of creatine kinase (>170 000 U/L) and cardiac troponin I (11 and 46 microg/L in patients one and two, respectively). Creatine kinase and cardiac troponin I values were highly correlated in each patent (r = 0.786 and 0.988 in patients one and two, respectively). Autopsy of one patient confirmed the diagnosis of skeletal and cardiac rhabdomyolysis.
丙泊酚，一种中枢性镇静剂，已被认为与儿童横纹肌溶解症的发生有关。我们描述了两名成年人，他们在接受高剂量丙泊酚输注后发生了横纹肌溶解症。两名患者的肌酸激酶（>170000 U/L）和心肌肌钙蛋白I（患者一和患者二分别为11和46 μg/L）显著升高，提示骨骼肌和心肌均发生了横纹肌溶解。每名患者的肌酸激酶和心肌肌钙蛋白I值高度相关（患者一和患者二的r分别为0.786和0.988）。对其中一名患者的尸检证实了骨骼肌和心肌横纹肌溶解症的诊断。
