Hanna J P, Ramundo M L
Department of Neurology, MetroHealth Medical Center, Cleveland, OH 44109, USA.
Neurology. 1998 Jan;50(1):301-3. doi: 10.1212/wnl.50.1.301.
Propofol, a new anesthetic, is now used more commonly to sedate patients in the intensive care unit. Propofol's rapid elimination has popularized its use to induce and maintain hypnosis in patients with refractory status epilepticus. It is also associated with occasional severe metabolic acidosis and hypoxia of indeterminate cause in children. We report a child and an adolescent who developed severe metabolic acidosis, progressive hypoxia, and rhabdomyolysis during maintenance infusion of propofol for the treatment of refractory status epilepticus. We suggest that propofol should not be used for prolonged sedation in children until its safety can be ensured.
丙泊酚是一种新型麻醉剂，目前在重症监护病房中更常用于使患者镇静。丙泊酚的快速消除使其在难治性癫痫持续状态患者中诱导和维持催眠的应用得到普及。它在儿童中还偶尔与原因不明的严重代谢性酸中毒和缺氧有关。我们报告了一名儿童和一名青少年，他们在输注丙泊酚治疗难治性癫痫持续状态的维持过程中出现了严重代谢性酸中毒、进行性缺氧和横纹肌溶解。我们建议，在确保丙泊酚安全性之前，不应将其用于儿童的长期镇静。
