赖氨酰内肽酶（Lif）和表皮溶素（Epr）将位点特异性丝氨酸掺入葡萄球菌肽聚糖交联桥的第3和第5位。
Site-specific serine incorporation by Lif and Epr into positions 3 and 5 of the Staphylococcal peptidoglycan interpeptide bridge.
作者信息
Ehlert K, Tschierske M, Mori C, Schröder W, Berger-Bächi B
机构信息
Bayer AG, PH Research Antiinfectives I, D-42096 Wuppertal, Germany.
出版信息
J Bacteriol. 2000 May;182(9):2635-8. doi: 10.1128/JB.182.9.2635-2638.2000.
Abstract
The FemAB-like factors Lif and Epr confer resistance to glycylglycine endopeptidases lysostaphin and Ale-1, respectively, by incorporating serine residues into the staphylococcal peptidoglycan interpeptide bridges specifically at positions 3 and 5. This required the presence of FemA and/or FemB, in contrast to earlier postulations.
摘要
FemAB样因子Lif和Epr分别通过将丝氨酸残基特异性地掺入葡萄球菌肽聚糖肽间桥的第3位和第5位，赋予对甘氨酰甘氨酸内肽酶溶葡萄球菌素和Ale-1的抗性。与早期假设相反，这需要FemA和/或FemB的存在。
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Lif, the lysostaphin immunity factor, complements FemB in staphylococcal peptidoglycan interpeptide bridge formation.
FEMS Microbiol Lett. 1997 Aug 15;153(2):261-4. doi: 10.1016/s0378-1097(97)00234-6.
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epr, which encodes glycylglycine endopeptidase resistance, is homologous to femAB and affects serine content of peptidoglycan cross bridges in Staphylococcus capitis and Staphylococcus aureus.
J Bacteriol. 1997 Jul;179(13):4311-8. doi: 10.1128/jb.179.13.4311-4318.1997.
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