Paky F, Kytir J
Abteilung für Kinder- und Jugendheilkunde des Landeskrankenhauses Mödling, Osterreich.
Wien Klin Wochenschr. 2000 Mar 10;112(5):193-7.
With the decline of the former main causes of death in early childhood--infections and starvation--sudden infant death syndrome (SIDS) has emerged as the most important single cause of postneonatal infant mortality. It has adopted the role of a major indicator for the standard of public health care. Despite extensive input into research, its pathophysiology has remained rather obscure. The resulting helplessness of scientists and health care professionals have lead to adherence to unconfirmed pathophysiological hypotheses and to pursuit of preventive strategies of doubtful efficacy. In this overview, the medical and technical background of five major hypotheses is being presented. A lot can be learnt from the history of their development, efforts to refute them, and the reasons for unreflected adherence to them. (1) Due to its illustrative nature, the so-called 'status thymico-lymphaticus', the theory of asphixation by an enlarged thymus, could not be eradicated although well-reknowned physicians--including the Austrian pathologist Paltauf--have repeatedly attempted to do so. (2) Assumed familiarity, an aspect which attracted the attention of pediatricians to SIDS initially has been excluded, but an increased risk of SIDS for the siblings of affected babies is still common belief. (3) The sleep-apnea-hypothesis has turned out a complete error with serious consequences, but home apnea monitors are still being widely recommended. (4) The rise of SIDS in the 80ies and its subsequent decline in the 90ies has been interpreted as the advent and successful control of an epidemic although significant numbers of cot death have been reported long before the turn of the century, and the apparent increase which paralleled the introduction of the 9th edition of the ICD code is most likely due to improved registration. (5) Finally, SIDS is still being considered a random event--ignoring all evidence of an obvious role of socioeconomical factors.
随着幼儿期以前的主要死因——感染和饥饿——的减少,婴儿猝死综合征(SIDS)已成为新生儿后期婴儿死亡的最重要单一原因。它已成为公共卫生保健标准的主要指标。尽管在研究方面投入巨大,但其病理生理学仍相当模糊。科学家和医护人员由此产生的无助感导致他们坚持未经证实的病理生理假设,并追求效果存疑的预防策略。在本综述中,将介绍五个主要假设的医学和技术背景。从它们的发展历程、反驳它们的努力以及不加思考地坚持它们的原因中可以学到很多东西。(1)由于其具有说明性,所谓的“胸腺淋巴体质”,即肿大胸腺导致窒息的理论,尽管包括奥地利病理学家帕尔陶夫在内的知名医生多次试图消除它,但仍无法根除。(2)假定的熟悉度,这一最初吸引儿科医生关注SIDS的方面已被排除,但受影响婴儿的兄弟姐妹患SIDS的风险增加仍然是普遍看法。(3)睡眠呼吸暂停假说已被证明是一个完全错误且后果严重,但家庭呼吸暂停监测仪仍被广泛推荐。(4)80年代SIDS的上升及其随后在90年代的下降被解释为一种流行病的出现和成功控制,尽管在世纪之交之前很久就有大量婴儿床死亡的报告,而且与国际疾病分类第9版的引入同时出现的明显增加很可能是由于登记的改善。(5)最后,SIDS仍被视为一个随机事件——忽略了所有表明社会经济因素具有明显作用的证据。