Wang L C, Lee T F
Department of Biological Sciences, University of Alberta, Edmonton, Canada.
Planta Med. 2000 Mar;66(2):144-7. doi: 10.1055/s-2000-11122.
Acute systemic injection of ginseng saponin (GS) significantly elevated both the total and maximum heat production in young rats (3-6 months) and improved their cold tolerance under severe cold (-10 degrees C under helium-oxygen). However, pretreating the animal with the optimal dose (10 mg/kg) of GS devoid of Rg1 and Rb1 failed to elicit any beneficial effect in improving the cold tolerance. Pretreating the animal with Rb1, but not Rg1, increased thermogenesis as well as cold tolerance in young rats. A similar beneficial effect in improving cold tolerance was also observed when old rats (26-28 months) were pretreated with the same doses of Rb1 (2.5 and 5.0 mg/kg). Our results indicate that Rb1 is the key ingredient in GS-mediated enhancement in thermogenic capacity and that both young and old rats can benefit from this treatment for enhanced cold tolerance.
急性全身注射人参皂苷（GS）可显著提高幼龄大鼠（3 - 6个月）的总产热和最大产热，并改善它们在严寒（氦氧环境下 - 10摄氏度）中的耐寒能力。然而，用不含Rg1和Rb1的最佳剂量（10 mg/kg）的GS预处理动物，未能在改善耐寒能力方面产生任何有益效果。用Rb1而非Rg1预处理动物，可增加幼龄大鼠的产热及耐寒能力。当老年大鼠（26 - 28个月）用相同剂量的Rb1（2.5和5.0 mg/kg）预处理时，也观察到了在改善耐寒能力方面的类似有益效果。我们的结果表明，Rb1是GS介导的产热能力增强的关键成分，并且幼龄和老年大鼠均可从这种增强耐寒能力的治疗中受益。
