Haruma K, Kamada T, Kawaguchi H, Okamoto S, Yoshihara M, Sumii K, Inoue M, Kishimoto S, Kajiyama G, Miyoshi A
First Department of Internal Medicine, Hiroshima University School of Medicine, Kasumi, Japan.
J Gastroenterol Hepatol. 2000 Mar;15(3):277-83. doi: 10.1046/j.1440-1746.2000.02131.x.
Whether gastric acid secretion decreases with age is still controversial. With the discovery of Helicobacter pylori, the association of this bacterium with gastric acid secretion has also been discussed. The aim of this study was to investigate the relationship between gastric acid secretion, age and H. pylori infection.
The presence of H. pylori infection, the grade of fundic atrophic gastritis (FAG), and gastric acid secretion were investigated in 280 subjects without localized lesions in the upper gastrointestinal tract. Helicobacter pylori infection was confirmed by Giemsa and immunohistochemical staining, and FAG of biopsy specimens was graded on a scale of 0-4.
Both basal and maximal acid output decreased with age in H. pylori-positive subjects, while they did not change with age in H. pylori-negative subjects. Gastric acid secretion decreased with the progression of FAG. An age-correlated decrease in gastric acid secretion in H. pylori-positive subjects depended on an increasing prevalence of FAG with age.
In the population studied, advancing age had no influence on gastric acid secretion in H. pylori-negative subjects. Gastric acid secretion decreases with age in H. pylori-positive subjects because of the increasing prevalence of FAG with age.
胃酸分泌是否随年龄增长而减少仍存在争议。随着幽门螺杆菌的发现，该细菌与胃酸分泌之间的关联也受到了讨论。本研究旨在探讨胃酸分泌、年龄与幽门螺杆菌感染之间的关系。
对280例无上消化道局限性病变的受试者进行幽门螺杆菌感染情况、胃底萎缩性胃炎（FAG）分级及胃酸分泌情况的调查。通过吉姆萨染色和免疫组化染色确认幽门螺杆菌感染，并将活检标本的FAG按0 - 4级进行分级。
幽门螺杆菌阳性受试者的基础胃酸分泌量和最大胃酸分泌量均随年龄增长而降低，而幽门螺杆菌阴性受试者的胃酸分泌量不随年龄变化。胃酸分泌量随FAG进展而降低。幽门螺杆菌阳性受试者中与年龄相关的胃酸分泌减少取决于FAG患病率随年龄的增加。
在所研究的人群中，年龄增长对幽门螺杆菌阴性受试者的胃酸分泌无影响。幽门螺杆菌阳性受试者的胃酸分泌量随年龄增长而降低是因为FAG患病率随年龄增加。
