Oki Shotaro, Takeda Tsutomu, Hojo Mariko, Uchida Ryota, Suzuki Nobuyuki, Abe Daiki, Ikeda Atsushi, Akazawa Yoichi, Ueyama Hiroya, Nojiri Shuko, Hoshino Shinichi, Shokita Hayashi, Nagahara Akihito
Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Medical Technology Innovation Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
J Clin Med. 2022 Sep 28;11(19):5739. doi: 10.3390/jcm11195739.
The incidence of gastric cancer in Okinawa Prefecture is the lowest in Japan, which is attributed to differences in strains of Helicobacter pylori in Okinawa and other prefectures in Japan. Our aim was to compare the endoscopic findings of H. pylori-infected gastric mucosa in Okinawa and Tokyo. Patients who underwent upper gastrointestinal endoscopy (UGI) at Northern Okinawa Medical Center (Okinawa group) and Juntendo University Hospital (Tokyo group) from April 2019 to March 2020 were included. Patients diagnosed with H. pylori-infected gastric mucosa were retrospectively compared between the Okinawa and Tokyo groups according to the Kyoto Classification of Gastritis. The numbers of subjects (Okinawa/Tokyo) were 435/352, male/female ratio was 247:188/181:171, and age was 53.3 ± 14.7/64.6 ± 14.3 (mean ± standard deviation) years. Regarding the Kyoto Classification of Gastritis, the prevalence (Okinawa/Tokyo) of the closed type of atrophic gastritis was 73%/37% (p < 0.001), diffuse redness 80%/84% (p = 0.145), mucosal swelling 46%/46% (p = 0.991), enlarged fold 26%/32% (p = 0.048), spotty redness 77%/68% (p = 0.002), sticky mucus 17%/36% (p < 0.001), and intestinal metaplasia 32%/42% (p < 0.001). Age analysis also revealed that closed-type atrophy and spotty redness were more frequent in the Okinawa group than in the Tokyo group. There may be regional differences in endoscopic findings of H. pylori-infected gastric mucosa between Okinawa and Tokyo.
冲绳县的胃癌发病率在日本是最低的，这归因于冲绳与日本其他县幽门螺杆菌菌株的差异。我们的目的是比较冲绳和东京幽门螺杆菌感染胃黏膜的内镜检查结果。纳入了2019年4月至2020年3月在冲绳北部医疗中心（冲绳组）和顺天堂大学医院（东京组）接受上消化道内镜检查（UGI）的患者。根据胃炎京都分类法，对诊断为幽门螺杆菌感染胃黏膜的患者在冲绳组和东京组之间进行回顾性比较。受试者数量（冲绳/东京）为435/352，男女比例为247:188/181:171，年龄为53.3±14.7/64.6±14.3（均值±标准差）岁。关于胃炎京都分类法，萎缩性胃炎闭合型的患病率（冲绳/东京）为73%/37%（p<0.001），弥漫性发红为80%/84%（p = 0.145），黏膜肿胀为46%/46%（p = 0.991），皱襞粗大为26%/32%（p = 0.048），点状发红为77%/68%（p = 0.002），黏液黏稠为17%/36%（p<0.001），肠化生为32%/42%（p<0.001）。年龄分析还显示，冲绳组闭合型萎缩和点状发红比东京组更常见。冲绳和东京幽门螺杆菌感染胃黏膜的内镜检查结果可能存在地区差异。
