Haruma K, Kawaguchi H, Kohmoto K, Okamoto S, Yoshihara M, Sumii K, Kajiyama G
First Dept. of Internal Medicine, Hiroshima University School of Medicine, Japan.
Scand J Gastroenterol. 1995 Apr;30(4):322-6. doi: 10.3109/00365529509093284.
Many studies have confirmed the close association of Helicobacter pylori with duodenal ulcer (DU) in adults. However, in the subtype of DU known as 'childhood' or 'early onset DU' genetic factors seem to play a prominent role in the pathogenesis. The aim of this study was to investigate the prevalence of H. pylori in teen-age subjects with DU, gastritis, and normal mucosa and to examine the relationship of H. pylori to serum gastrin levels and gastric acid secretion.
Sixty-one teen-age subjects (24 with DU, 14 with gastritis, and 23 normal subjects) were investigated for the presence of H. pylori, antral histology, gastrin levels, basal acid output (BAO), and maximal acid output (MAO).
All 24 patients with DU and 8 of 14 with gastritis were infected with H. pylori; none of the normal subjects were infected. Mean gastritis scores and fasting serum gastrin levels were significantly higher in patients with DU or H. pylori-positive gastritis than in subjects with H. pylori-negative gastritis or normal mucosa (p < 0.05). The difference in serum gastrin levels was also significant when patients with DU were compared with those with H. pylori-positive gastritis (p < 0.05). BAO and MAO were significantly higher in patients with DU than in subjects with H. pylori-positive gastritis or normal mucosa (p < 0.05), but there was no difference between subjects with H. pylori-positive gastritis and those with normal mucosa.
H. pylori infection is associated closely with teen-age DU and gastritis and with hypergastrinemia but does not affect BAO and MAO in most infected teen-age subjects.
许多研究已证实幽门螺杆菌与成人十二指肠溃疡（DU）密切相关。然而，在被称为“儿童期”或“早发性DU”的DU亚型中，遗传因素似乎在发病机制中起重要作用。本研究的目的是调查青少年DU患者、胃炎患者和正常黏膜者中幽门螺杆菌的感染率，并研究幽门螺杆菌与血清胃泌素水平及胃酸分泌的关系。
对61名青少年（24例DU患者、14例胃炎患者和23名正常受试者）进行了幽门螺杆菌检测、胃窦组织学检查、胃泌素水平测定、基础胃酸分泌量（BAO）和最大胃酸分泌量（MAO）检测。
24例DU患者和14例胃炎患者中的8例感染了幽门螺杆菌；正常受试者均未感染。DU患者或幽门螺杆菌阳性胃炎患者的平均胃炎评分和空腹血清胃泌素水平显著高于幽门螺杆菌阴性胃炎患者或正常黏膜者（p<0.05）。将DU患者与幽门螺杆菌阳性胃炎患者进行比较时，血清胃泌素水平的差异也具有统计学意义（p<0.05）。DU患者的BAO和MAO显著高于幽门螺杆菌阳性胃炎患者或正常黏膜者（p<0.05），但幽门螺杆菌阳性胃炎患者与正常黏膜者之间无差异。
幽门螺杆菌感染与青少年DU、胃炎及高胃泌素血症密切相关，但在大多数受感染的青少年受试者中不影响BAO和MAO。
