Ko G T, Chan J C, Lau M, Cockram C S
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, People's Republic of China.
J Diabetes Complications. 1999 Sep-Dec;13(5-6):300-6. doi: 10.1016/s1056-8727(99)00063-x.
Microangiopathic complications are major causes of morbidity and mortality in diabetic patients. We studied 150 consecutive young Chinese diabetic subjects attending the Prince of Wales Hospital Diabetes Center on their presence of diabetic microangiopathic complications and the relationships with other risk factors. All patients with aged younger than 40 years and had an age of onset of disease at younger than 35 years. Their known duration of diabetes was 57.2 +/- 5.0 months. Of these 150 patients, 50 (33.3%) had microangiopathic complications, 34 (22.7%) had albuminuria, 11 (7. 3%) had peripheral neuropathy, and 21 (14%) had retinopathy. Using multiple logistic regression analysis, albuminuria was independently associated with body-mass index and systolic blood pressure, peripheral neuropathy was associated with fasting plasma glucose and lower high-density lipoprotein cholesterol, and retinopathy was associated with duration of disease and fasting plasma glucose. In conclusion, there were high percentages of microangiopathic complications, particularly albuminuria, in our young Chinese diabetic patients. Obesity, high blood pressure, and poor glycemic control are important for these complications.
微血管并发症是糖尿病患者发病和死亡的主要原因。我们研究了150例连续就诊于威尔士亲王医院糖尿病中心的中国年轻糖尿病患者，观察他们是否存在糖尿病微血管并发症以及这些并发症与其他危险因素之间的关系。所有患者年龄均小于40岁，发病年龄小于35岁。他们已知的糖尿病病程为57.2±5.0个月。在这150例患者中，50例（33.3%）有微血管并发症，34例（22.7%）有蛋白尿，11例（7.3%）有周围神经病变，21例（14%）有视网膜病变。采用多因素logistic回归分析，蛋白尿与体重指数和收缩压独立相关，周围神经病变与空腹血糖及较低的高密度脂蛋白胆固醇相关，视网膜病变与病程和空腹血糖相关。总之，我们的中国年轻糖尿病患者中微血管并发症，尤其是蛋白尿的发生率很高。肥胖、高血压和血糖控制不佳对这些并发症很重要。
