Afkhami-Ardekani M, Modarresi M, Amirchaghmaghi E
Diabetes Research Center, Sadoughi University of Medical Sciences and Health Services of Yazd, Iran.
Indian J Nephrol. 2008 Jul;18(3):112-7. doi: 10.4103/0971-4065.43690.
A cross-sectional study was performed from November 2005 to July 2007 to determine the prevalence of microalbuminuria and its risk factors among type 2 diabetic patients.. Two hundred and eighty-eight type 2 diabetic patients (141 males and 147 females) referred to Yazd diabetes research center were randomly recruited for the study. Microalbuminuria was detected by measuring the albumin to creatinine ratio in the early morning urine. Microalbuminuria was diagnosed if this ratio was between 30 and 300 mg/g on two occasions during three months. Prevalence of microalbuminuria was 14.2%. Chi-square analysis revealed that microalbuminuria was correlated with the diastolic blood pressure (P = 0.003) and the duration of diabetes (P = 0.000). No statistically significant correlation was found between microalbuminuria and age, sex, body mass index, levels of fasting blood sugar, glycosylated hemoglobin (HbA1c), serum triglyceride, and serum cholesterol, or systolic blood pressure. For 240 patients for whom the duration of diabetes was known from the answers in their questionnaires, logistic regression was used for analysis. Results showed that two variables including the duration of diabetes and Diastolic Blood Pressure (DBP) play a role in this model and the following Logic association was obtained: g; (x) = -9.233 +/- 0.079 DBP +/- 0.114 duration according to this model, both DBP and duration of diabetes were directly correlated with microalbuminuria. Determination of the urine albumin to creatinine ratio is an easy method for screening of microalbuminuria that is suggested for all diabetic patients, especially diabetic patients with hypertension and long-term diabetes.
2005年11月至2007年7月进行了一项横断面研究，以确定2型糖尿病患者中微量白蛋白尿的患病率及其危险因素。随机招募了288名转诊至亚兹德糖尿病研究中心的2型糖尿病患者（141名男性和147名女性）参与该研究。通过测量晨尿中的白蛋白与肌酐比值来检测微量白蛋白尿。如果在三个月内两次测量该比值在30至300mg/g之间，则诊断为微量白蛋白尿。微量白蛋白尿的患病率为14.2%。卡方分析显示，微量白蛋白尿与舒张压（P = 0.003）和糖尿病病程（P = 0.000）相关。未发现微量白蛋白尿与年龄、性别、体重指数、空腹血糖水平、糖化血红蛋白（HbA1c）、血清甘油三酯和血清胆固醇或收缩压之间存在统计学显著相关性。对于240名从问卷答案中得知糖尿病病程的患者，采用逻辑回归进行分析。结果表明，糖尿病病程和舒张压这两个变量在该模型中起作用，并得到以下逻辑关联：g; (x) = -9.233 +/- 0.079舒张压 +/- 0.114病程。根据该模型，舒张压和糖尿病病程均与微量白蛋白尿直接相关。测定尿白蛋白与肌酐比值是一种筛查微量白蛋白尿的简便方法，建议所有糖尿病患者，尤其是患有高血压和长期糖尿病的患者使用。
