Edert D Y, Finance C M, Le Faou A E
UMR UHP-CNRS 7565, Laboratoire de Virologie, CHU de Nancy, Hôpital de Brabois, Vandoeuvre-lès-Nancy, France.
Chemotherapy. 2000 May-Jun;46(3):195-7. doi: 10.1159/000007278.
The susceptibility of clinical isolates of herpes simplex virus 1 (HSV1) (58 strains) and 2 (HSV2) (17 strains) from the Centre Hospitalier et Universitaire de Nancy to three nucleoside analogues was compared by the dye uptake method. As expected, all strains of HSV2 were resistant to brovavir or sorivudine. Aciclovir and penciclovir activities were comparable; 2 strains of HSV1 were resistant to these two compounds. Four strains isolated from immunocompromised patients gave different results with brovavir as compared to aciclovir; resistance to aciclovir (1 strain of HSV1) did not correlate with resistance to brovavir (3 strains of HSV1). Following up antiviral susceptibility is of interest for the detection of resistant strains in immunocompromised patients receiving prophylactic aciclovir.
采用染料摄取法比较了南锡大学中心医院分离出的58株单纯疱疹病毒1型（HSV1）和17株单纯疱疹病毒2型（HSV2）临床分离株对三种核苷类似物的敏感性。正如预期的那样，所有HSV2毒株对溴夫定或索立夫定耐药。阿昔洛韦和喷昔洛韦的活性相当；2株HSV1对这两种化合物耐药。与阿昔洛韦相比，从免疫功能低下患者中分离出的4株毒株对溴夫定的结果不同；对阿昔洛韦耐药（1株HSV1）与对溴夫定耐药（3株HSV1）无关。对于接受预防性阿昔洛韦治疗的免疫功能低下患者，跟踪抗病毒药物敏感性对于检测耐药菌株具有重要意义。
