喷昔洛韦对阿昔洛韦耐药和膦甲酸钠耐药单纯疱疹病毒临床分离株的体外活性
In vitro activity of penciclovir against clinical isolates of acyclovir-resistant and foscarnet-resistant herpes simplex virus.
作者信息
Safrin S, Phan L
机构信息
Department of Medicine, University of California-San Francisco.
出版信息
Antimicrob Agents Chemother. 1993 Oct;37(10):2241-3. doi: 10.1128/AAC.37.10.2241.
Abstract
We tested 23 clinical isolates of acyclovir-susceptible, acyclovir-resistant, and foscarnet-resistant herpes simplex virus for susceptibility to penciclovir. Isolates showed cross-resistance to penciclovir and acyclovir, but penciclovir retained a relative activity against foscarnet-resistant isolates. Its clinical utility for the treatment of resistant herpes simplex virus infections remains to be studied.
摘要
我们检测了23株对阿昔洛韦敏感、耐阿昔洛韦和耐膦甲酸钠的单纯疱疹病毒临床分离株对喷昔洛韦的敏感性。分离株显示出对喷昔洛韦和阿昔洛韦的交叉耐药性，但喷昔洛韦对耐膦甲酸钠的分离株仍保留相对活性。其在治疗耐药单纯疱疹病毒感染方面的临床效用仍有待研究。
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