Buchheidt D, Skladny H, Baust C, Hehlmann R
Medizinische Universitätsklinik, Klinikum Mannheim der Universität Heidelberg, Mannheim, Deutschland.
Chemotherapy. 2000 May-Jun;46(3):219-28. doi: 10.1159/000007283.
Within recent years, novel serological and molecular methods have been developed to improve the early diagnosis of invasive fungal infections especially in patients with malignant hematological diseases being at highest risk of developing these life-threatening infections. Early diagnosis is essential for adequate therapeutic management, which, however, often remains difficult since the diagnostic tools clinically used either lack specificity or sensitivity, or both at worst. The clinical value, the advantages and remaining problems of recently developed, more sensitive and specific serological assays and molecular methods are reviewed.
近年来，已开发出新型血清学和分子方法，以改善侵袭性真菌感染的早期诊断，尤其是在罹患这些危及生命感染风险最高的恶性血液病患者中。早期诊断对于适当的治疗管理至关重要，然而，这往往仍然很困难，因为临床使用的诊断工具要么缺乏特异性，要么缺乏敏感性，或者在最糟糕的情况下两者都缺乏。本文综述了最近开发的、更敏感和特异的血清学检测方法和分子方法的临床价值、优点及尚存的问题。
