Buchheidt D, Spiess B, Hehlmann R
3. Medizinische Klinik, Universitätsklinikum Mannheim, Ruprecht-Karls-Universität Heidelberg, Germany.
Onkologie. 2001 Dec;24(6):531-6. doi: 10.1159/000055140.
Within the recent years, novel molecular and serological methods have been developed to improve the diagnosis of invasive aspergillosis in patients with malignant hematological diseases being at highest risk for this life-threatening infection. Early diagnosis and treatment are essential for adequate therapeutic management, which, however, often remains difficult since most of the diagnostic tools used clinically at present either lack specificity or sensitivity, or both at the worst. The clinical value, advantages and remaining problems of recently developed serological assays and molecular approaches to detect this emerging pathogen are reviewed.
近年来，已开发出新型分子和血清学方法，以改善对恶性血液病患者侵袭性曲霉病的诊断，这些患者面临这种危及生命感染的最高风险。早期诊断和治疗对于适当的治疗管理至关重要，然而，这往往仍然很困难，因为目前临床上使用的大多数诊断工具要么缺乏特异性，要么缺乏敏感性，或者在最糟糕的情况下两者都缺乏。本文综述了最近开发的用于检测这种新出现病原体的血清学检测方法和分子方法的临床价值、优点及尚存问题。
