Rurangirwa F R, Stiller D, Palmer G H
Program in Vector-Borne Diseases, Washington State University, Pullman, Washington 99164-7040, USA.
Infect Immun. 2000 May;68(5):3023-7. doi: 10.1128/IAI.68.5.3023-3027.2000.
Specific major surface protein 2 (MSP2) variants are expressed by Anaplasma marginale within the tick salivary gland and, following transmission, are expressed during acute rickettsemia. In previous work, we have shown that a restricted pattern of MSP2 variants is expressed in the salivary glands of Dermacentor andersoni ticks infected with the South Idaho strain of A. marginale. Now we demonstrate that the identical restriction does not apply to two other strains of A. marginale, and that different variants are also expressed when the same strain is transmitted by different Dermacentor spp. This indicates that antigenic diversity among strains is maintained in tick transmission and may be a significant constraint to MSP2 vaccine development.
特定主要表面蛋白2（MSP2）变体由边缘无形体在蜱唾液腺内表达，并且在传播后，在急性立克次体血症期间表达。在先前的工作中，我们已经表明，感染南爱达荷州边缘无形体菌株的安德逊革蜱唾液腺中表达的MSP2变体模式受限。现在我们证明，相同的限制不适用于边缘无形体的其他两个菌株，并且当同一菌株由不同的革蜱属传播时也会表达不同的变体。这表明菌株之间的抗原多样性在蜱传播中得以维持，并且可能是MSP2疫苗开发的一个重大限制。
