Kagawa Y, Yoshida K, Hirai T, Toge T, Yokozaki H, Yasui W, Tahara E
Department of Surgical Oncology, School of Medicine, Hiroshima University, Japan.
Anticancer Res. 2000 Jan-Feb;20(1A):213-7.
Microsatellite instability (MSI) caused by the defective functions of mismatch repair genes plays an important role in the carcinogenesis of gastrointestinal tumors. However, little is known about the role of MSI in esophageal carcinogenesis. In the present study, we conducted microsatellite assays on 41 esophageal carcinomas and also on 44 dysplasias of the esophagus with 7 separate microsatellite loci. MSI was detected in 17 cases (42%) among 41 esophageal carcinomas. MSI negative cases revealed greater lymph node metastasis, metastasis at a more advanced stage, a higher recurrence level and a poorer prognosis (statistically not significant). In the analysis of dysplasias, MSI was detected in 26 lesions (59%) among 44 lesions. Interestingly, MSI was detected in 21 lesions (78%) from the mutator phenotype dysplasias, but detected in only 5 lesions (29%) from the non-mutator phenotype cases. Although the significance of MSI in esophageal carcinoma was not clear, these results indicate that MSI occurs in the early stage of esophageal carcinogenesis.
错配修复基因功能缺陷导致的微卫星不稳定性（MSI）在胃肠道肿瘤的致癌过程中起重要作用。然而，关于MSI在食管癌发生中的作用知之甚少。在本研究中，我们对41例食管癌以及44例食管发育异常组织进行了微卫星检测，使用7个独立的微卫星位点。在41例食管癌中，17例（42%）检测到MSI。MSI阴性病例显示出更高的淋巴结转移率、更晚期的转移、更高的复发率和更差的预后（统计学上无显著差异）。在发育异常组织的分析中，44个病变中有26个（59%）检测到MSI。有趣的是，在具有突变体表型的发育异常组织中有21个病变（78%）检测到MSI，而在非突变体表型病例中仅5个病变（29%）检测到MSI。虽然MSI在食管癌中的意义尚不清楚，但这些结果表明MSI发生在食管癌发生的早期阶段。
