抗菌剂与百日咳博德特氏菌周质百日咳毒素的释放
Antibacterial agents and release of periplasmic pertussis toxin from Bordetella pertussis.
作者信息
Craig-Mylius K A, Weiss A A
机构信息
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267-0524, USA.
出版信息
Antimicrob Agents Chemother. 2000 May;44(5):1383-6. doi: 10.1128/AAC.44.5.1383-1386.2000.
Abstract
Pertussis toxin accumulates in the periplasm of Bordetella pertussis prior to secretion, and we examined its fate following treatment with antimicrobial agents. Both antibiotics that inhibit protein synthesis (erythromycin and chloramphenicol), transcription (rifampin), or cell wall biosynthesis (cefoperazone and piperacillin) and magnesium sulfate (which inhibits transcription of pertussis toxin, but not bacterial growth) did not prevent release of preformed toxin. In contrast, agents that affect bacterial membranes, such as polymyxin B, lidocaine, procaine, and ethanol, inhibited release of preformed pertussis toxin. These results suggest new protein synthesis is not required for pertussis toxin secretion, but a functional membrane complex is required.
摘要
百日咳毒素在分泌前积聚在百日咳博德特氏菌的周质中，我们研究了其在用抗菌剂处理后的去向。抑制蛋白质合成（红霉素和氯霉素）、转录（利福平）或细胞壁生物合成（头孢哌酮和哌拉西林）的抗生素以及硫酸镁（抑制百日咳毒素转录，但不抑制细菌生长）均不能阻止预先形成的毒素释放。相比之下，影响细菌膜的药物，如多粘菌素B、利多卡因、普鲁卡因和乙醇，抑制预先形成的百日咳毒素释放。这些结果表明，百日咳毒素分泌不需要新的蛋白质合成，但需要功能性膜复合物。
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