Laborie S, Lavoie J C, Pineault M, Chessex P
Research Center, Hospital Ste-Justine, University of Montreal, Quebec, Canada.
Ann Pharmacother. 2000 Apr;34(4):440-5. doi: 10.1345/aph.19182.
To compare the concentrations of peroxides between adult and neonatal total parenteral nutrition (TPN) solutions in response to protection against inducers of peroxidation such as multivitamins and exposure to light or air.
Peroxide concentrations were measured in freshly prepared adult and neonatal solutions of fat-free TPN in four settings: with or without an air inlet, and protected or unprotected from ambient light. An oxygen washout was performed by exposing a fat-free neonatal TPN solution to a continuous flow of nitrogen.
Globally, light was the main inducer of peroxides in adult and neonatal solutions. However, in adult solutions the concentration of peroxides remained <15 micromol/L, while in neonatal solutions the peroxide concentration was as high as 300 micromol/L in ambient light. Although the oxygen washout did prevent the generation of peroxides, avoiding air inlet was not as effective as was photoprotection in decreasing the important peroxide load in the neonatal TPN solution.
The higher concentration of peroxides found in neonatal solutions compared with adult solutions is explained by the differences in nutrient composition between the two solutions. Contamination of parenteral solutions by air during compounding accounts for the photoinduced generation of peroxides in TPN solutions. It is more convenient to protect TPN solutions from light exposure after the admixture of the multivitamin solution than to avoid contact with oxygen.
比较成人和新生儿全胃肠外营养（TPN）溶液中过氧化物的浓度，以应对抗氧化剂（如多种维生素）以及暴露于光或空气中等过氧化诱导因素。
在四种情况下测量新鲜配制的成人和新生儿无脂TPN溶液中的过氧化物浓度：有无进气口，以及是否受到环境光的保护。通过将无脂新生儿TPN溶液暴露于连续的氮气流中来进行氧气冲洗。
总体而言，光在成人和新生儿溶液中是过氧化物的主要诱导因素。然而，在成人溶液中过氧化物浓度仍<15微摩尔/升，而在新生儿溶液中，在环境光下过氧化物浓度高达300微摩尔/升。尽管氧气冲洗确实能防止过氧化物的产生，但在降低新生儿TPN溶液中重要的过氧化物负荷方面，避免进气不如光保护有效。
与成人溶液相比，新生儿溶液中过氧化物浓度较高是由两种溶液营养成分的差异所致。配制过程中肠外溶液被空气污染导致TPN溶液中过氧化物的光诱导生成。在多种维生素溶液混合后保护TPN溶液免受光照比避免与氧气接触更方便。
