McCollom R A, Elbe D H, Ritchie A H
Department of Pharmacy, The Richmond Hospital, British Columbia, Canada.
Ann Pharmacother. 2000 Apr;34(4):471-3. doi: 10.1345/aph.19297.
To report three cases of serum sickness-like reaction (SSLR) associated with bupropion ingestion.
A 27-year-old woman, a 46-year-old man, and a 43-year-old woman presented to our emergency department within a three-week period with symptoms consistent with SSLR. Symptoms consisted of pruritic skin rash, tongue swelling, and arthralgias. All three patients had initiated bupropion therapy within two to three weeks prior to arrival.
This is the second published case describing SSLRs associated with bupropion. Reports of urticaria and rash with bupropion use are numerous and the incidence has been estimated at between 1% and 4%. Arthralgia and arthropathy with bupropion use are reported much less commonly. The onset of symptoms of SSLRs typically begins six to 21 days after administration of the causative agent. SSLRs are usually self-limiting, lasting four to 14 days.
SSLRs following bupropion ingestion appear to be rare. However, the fact that this cluster of patients presented to our emergency department within a three-week period suggests that this reaction may be underreported.
报告3例与安非他酮摄入相关的血清病样反应（SSLR）。
一名27岁女性、一名46岁男性和一名43岁女性在三周内就诊于我院急诊科，症状符合血清病样反应。症状包括瘙痒性皮疹、舌头肿胀和关节痛。所有3例患者在就诊前两到三周内开始使用安非他酮治疗。
这是第二篇发表的描述与安非他酮相关的血清病样反应的病例。使用安非他酮出现荨麻疹和皮疹的报告很多，估计发生率在1%至4%之间。使用安非他酮出现关节痛和关节病的报告则少得多。血清病样反应的症状通常在接触致病因子后6至21天开始出现。血清病样反应通常为自限性，持续4至14天。
摄入安非他酮后出现血清病样反应似乎很罕见。然而，这组患者在三周内就诊于我院急诊科这一事实表明，这种反应可能未得到充分报告。
