Cabrera T, Salinero J, Fernandez M A, Garrido A, Esquivias J, Garrido F
Departamento de Análisis Clínicos, Universidad de Granada, Spain.
Hum Immunol. 2000 May;61(5):499-506. doi: 10.1016/s0198-8859(00)00097-5.
The exact frequency of HLA class I losses in human tumors is unknown. We have previously shown that primary breast and colorectal carcinomas frequently lose HLA class I molecules (88% and 73%, respectively). Now we report that this phenomenon is also a frequent event in laryngeal carcinomas. Of a total of 76 laryngeal carcinomas analyzed, 66% of the tumors showed an alteration in HLA class I phenotype. These altered HLA phenotypes were classified as total HLA loss (10.52%) (phenotype I); HLA-A locus-specific loss (13.15%) (phenotype IIIa); HLA-B locus-specific loss (10.52%) (phenotype IIIb); HLA allelic loss (27.63%) (phenotype IV); and HLA-A and B locus loss (3.9%). Comparison of histopathological parameters with HLA expression showed that poorly differentiated tumors had the lowest levels of HLA class I expression (p < 0.05).
人类肿瘤中HLA I类分子缺失的确切频率尚不清楚。我们之前已经表明，原发性乳腺癌和结直肠癌经常丢失HLA I类分子（分别为88%和73%）。现在我们报告，这种现象在喉癌中也是常见事件。在总共分析的76例喉癌中，66%的肿瘤显示HLA I类表型改变。这些改变的HLA表型被分类为HLA完全缺失（10.52%）（表型I）；HLA - A基因座特异性缺失（13.15%）（表型IIIa）；HLA - B基因座特异性缺失（10.52%）（表型IIIb）；HLA等位基因缺失（27.63%）（表型IV）；以及HLA - A和B基因座缺失（3.9%）。组织病理学参数与HLA表达的比较表明，低分化肿瘤的HLA I类表达水平最低（p < 0.05）。
