3'-脱氧-3'-[(18)F]氟胸苷的放射性合成：[(18)F]FLT用于体内细胞增殖成像
Radiosynthesis of 3'-deoxy-3'-[(18)F]fluorothymidine: [(18)F]FLT for imaging of cellular proliferation in vivo.
作者信息
Grierson J R, Shields A F
机构信息
Research Imaging Laboratory, University of Washington Medical Center, Seattle, Washington 98195, USA.
出版信息
Nucl Med Biol. 2000 Feb;27(2):143-56. doi: 10.1016/s0969-8051(99)00104-3.
A reliable radiosynthesis of 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) has been developed based on [(18)10 mCi (370 MBq) of radiochemically pure [(18)1 Ci/micromol (37 GBq/micromol) at EOS within 100 min and in 13% radiochemical yield (end of bombardment (EOB); 7% end of synthesis (EOS)). [(18)F]FLT has been designed as a new positron emission tomography imaging agent for visualizing cellular proliferation in vivo based on the metabolism of thymidine.
基于[（18）F]氟代胸苷（[（18）F]FLT）的可靠放射性合成方法已被开发出来。在100分钟内，以1居里/微摩尔（37吉贝可/微摩尔）的比活度，在轰击结束时（EOB）获得了10毫居里（370兆贝可）的放射化学纯[（18）F]FLT，在合成结束时（EOS）产率为13%（EOB时为7%）。[（18）F]FLT被设计为一种新的正电子发射断层显像剂，用于基于胸苷代谢在体内可视化细胞增殖。
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