Mnyika S K, Kabalimu T K, Mbaruku G, Masisila R, Mpanju-Shumbusho W
Department of Epidemiology and Biostatistics, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania.
East Afr Med J. 2000 Feb;77(2):105-10. doi: 10.4314/eamj.v77i2.46410.
To determine baseline data among pregnant women consenting to participate in a randomised trial of alternative strategies of malaria chemoprophylaxis in Kigoma urban district, western Tanzania.
Cross-sectional study.
The study was conducted in an urban MCH clinic in Kigoma town in western Tanzania.
All consenting pregnant women who fulfilled entry criteria were recruited into the study. BASELINE STUDIES: Baseline data were collected prior to randomisation of women to antimalarial prophylactic regimens. Baseline measurements included examination for blood depleting parasitic infections (stool and urine examinations), haemoglobin levels, haematocrit, sickling test, and blood slide for malaria parasites.
A total of 728 pregnant women consented to participate in the interview and of these 705 participated in baseline studies constituting a participation rate of 96.8%. The age of participating women ranged from 14 to 45 years with a mean age of 23.7 years (standard deviation [SD] = 5.4) while the mean number of pregnancies ranged from 1 to 13 with a mean of 3.2 (SD = 2.2). The prevalence of malaria parasitaemia among the pregnant women examined was 9.4% (N = 705) while the prevalence of anaemia (defined as Hb < 8.5 gdl-1) was 12.4% (N = 579). No significant difference was observed in prevalence proportions of malaria parasitaemia in relation to age, parity, marital status and use of mosquito bednets. However the prevalence of anaemia among women in the age group 31-45 years was significantly lower than that observed among women in the age group 14-20 years (2.9% versus 18.9%; crude odds ratio [OR] = 0.13; 95% confidence interval [CI], 0.02-0.55). Sickle cell disease (HbAS) was found in 2.3% (N = 564) of the pregnant women examined.
It is concluded that the prevalence of malaria parasitaemia and anaemia was very high in this population suggesting the need for interventions directed at controlling these major causes of maternal morbidity and mortality in Tanzania.
确定坦桑尼亚西部基戈马市区同意参与疟疾化学预防替代策略随机试验的孕妇的基线数据。
横断面研究。
研究在坦桑尼亚西部基戈马镇的一家城市妇幼保健诊所进行。
所有符合入选标准并同意参与的孕妇均被纳入研究。基线研究：在将女性随机分配到抗疟疾预防方案之前收集基线数据。基线测量包括检查血液消耗性寄生虫感染（粪便和尿液检查）、血红蛋白水平、血细胞比容、镰状试验以及疟原虫血涂片检查。
共有728名孕妇同意参与访谈，其中705名参与了基线研究，参与率为96.8%。参与研究的女性年龄在14至45岁之间，平均年龄为23.7岁（标准差[SD]=5.4），而平均怀孕次数在1至13次之间，平均为3.2次（SD=2.2）。接受检查的孕妇中疟原虫血症的患病率为9.4%（N=705），而贫血患病率（定义为血红蛋白<8.5 g/dl-1）为12.4%（N=579）。在疟原虫血症患病率方面，未观察到与年龄、胎次、婚姻状况和使用蚊帐之间存在显著差异。然而，31至45岁年龄组女性的贫血患病率显著低于14至20岁年龄组女性（2.9%对18.9%；粗比值比[OR]=0.13；95%置信区间[CI]，0.02 - 0.55）。在接受检查的孕妇中，镰状细胞病（HbAS）的发现率为2.3%（N=564）。
得出结论，该人群中疟原虫血症和贫血的患病率非常高，这表明需要采取干预措施来控制坦桑尼亚孕产妇发病和死亡的这些主要原因。
