Krishnakumar K, Augusti K T, Vijayammal P L
Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram.
Indian J Physiol Pharmacol. 1999 Oct;43(4):510-4.
The petroleum ether extract of the root bark of S. oblonga Wall. (Celastraceae) (SOB) was studied in streptozotocin (STZ) diabetic rats and anti-lipid peroxidative activity of the same was studied in the cardiac tissue. SOB prevented significantly the streptozotocin-induced hyperglycaemia and hypoinsulinaemia. It also produced a significant decrease in peroxidation products viz. thiobarbituric acid reactive substances (P < 0.001), conjugated dienes (P < 0.05), hydroperoxides (P < 0.001). The activity of antioxidant enzymes such as superoxide dismutase (P < 0.001), catalase (P < 0.001), GSHPxase and GSSGRase was found to be increased in the heart tissue of diabetic animals treated with SOB. These results suggest that S. oblonga root bark extract possesses anti-diabetic and anti-oxidative activity in streptozotocin-diabetic rats.
对长圆叶安息香（野茉莉科）根皮的石油醚提取物（SOB）在链脲佐菌素（STZ）诱导的糖尿病大鼠中进行了研究，并对其在心脏组织中的抗脂质过氧化活性进行了研究。SOB显著预防了链脲佐菌素诱导的高血糖和低胰岛素血症。它还使过氧化产物即硫代巴比妥酸反应性物质（P < 0.001）、共轭二烯（P < 0.05）、氢过氧化物（P < 0.001）显著减少。在用SOB治疗的糖尿病动物的心脏组织中，发现抗氧化酶如超氧化物歧化酶（P < 0.001）、过氧化氢酶（P < 0.001）、谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活性增加。这些结果表明，长圆叶安息香根皮提取物在链脲佐菌素诱导的糖尿病大鼠中具有抗糖尿病和抗氧化活性。
