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卡波西肉瘤相关疱疹病毒：从细胞生物学到发病机制

Kaposi's sarcoma-associated herpesvirus: from cell biology to pathogenesis.

作者信息

Sharp T V, Boshoff C

机构信息

Department of Oncology, University College London, United Kingdom.

出版信息

IUBMB Life. 2000 Feb;49(2):97-104. doi: 10.1080/15216540050022395.

DOI:10.1080/15216540050022395
PMID:10776590
Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) is linked to the etiopathogenesis of Kaposi's sarcoma, a plasma-blastic variant of Castleman's disease and primary effusion lymphoma. KSHV is related to a number of non-human primate viruses. Only a limited number of KSHV proteins are expressed in tumor cells. Here we discuss the putative role of these proteins in KSHV pathogenesis.

摘要

卡波西肉瘤相关疱疹病毒（KSHV 或 HHV-8）与卡波西肉瘤、Castleman 病的浆母细胞变异型以及原发性渗出性淋巴瘤的发病机制相关。KSHV 与多种非人类灵长类病毒有关。在肿瘤细胞中仅表达有限数量的 KSHV 蛋白。在此，我们讨论这些蛋白在 KSHV 发病机制中的假定作用。

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