Medeiros C C, Marini S H, Baptista M T, Guerra G, Maciel-Guerra A T
Department of Pediatrics, Faculty of Medical Sciences, State University of Campinas (UNICAMP), São Paulo, Brazil.
J Pediatr Endocrinol Metab. 2000 Apr;13(4):357-62. doi: 10.1515/jpem.2000.13.4.357.
An increased prevalence of autoimmune thyroid disease (AITD) has been described in Turner's syndrome (TS), but the extent of this association is still controversial. Some studies also suggest that AITD is more frequent among patients with X-isochromosome. In order to determine the prevalence of AITD among girls with TS, and to look for an association with age and karyotype, we evaluated 71 patients with a mean age of 11.4 years (range 0-19.9). 15.5% (11/71) were hypothyroid, 17 (23.9%) were positive for thyroid peroxidase (TPO) and/or thyroglobulin (Tg) antibodies, and 24 (33.8%) had thyromegaly. No abnormality was observed before 4 years, and the highest frequencies were observed after 16 years. There were no significant differences concerning thyroid findings among patients with a 45,X karyotype, mosaics, and structural rearrangements. Half of the patients (35/71) exhibited one or more abnormalities, which demonstrates the importance of careful evaluation of thyroid function in all girls with TS.
已有研究表明，特纳综合征（TS）患者自身免疫性甲状腺疾病（AITD）的患病率有所增加，但这种关联的程度仍存在争议。一些研究还表明，X等臂染色体患者中AITD更为常见。为了确定TS女童中AITD的患病率，并寻找其与年龄和核型的关联，我们评估了71例平均年龄为11.4岁（范围0 - 19.9岁）的患者。15.5%（11/71）为甲状腺功能减退，17例（23.9%）甲状腺过氧化物酶（TPO）和/或甲状腺球蛋白（Tg）抗体呈阳性，24例（33.8%）有甲状腺肿大。4岁前未观察到异常，16岁后观察到的频率最高。45,X核型、嵌合体和结构重排患者的甲状腺检查结果无显著差异。一半的患者（35/71）表现出一种或多种异常，这表明对所有TS女童进行甲状腺功能仔细评估的重要性。
