Chakrabarti S, Bhunia C, Bhattacharya D K
Centre for Transfusion Medicine and Clinical Research, Calcutta.
J Assoc Physicians India. 1999 May;47(5):496-8.
Antiphospholipid antibodies (aPL) are a diverse family of autoantibodies reactive against negatively charged phospholipid-protein complexes. The clinically significant members include lupus anticoagulant (LA), anticardiolipin antibody (aCL) and reaginic antibodies causing biological false positive (BFP) venereal disease laboratory test (VDRL). Although detected in various clinical scenarios, unexplained fetal loss in women of reproductive age group is the commonest association. Fifty pregnant women of first and second trimester with a history of two or more unexplained pregnancy losses were studied for the presence of LA, aCL and reaginic antibodies. Thirty pregnant women of the same trimester without any history of fetal loss were taken as control. LA was detected in nine (18%) cases and aCL in 12 (24%) cases of the study group. The control group was negative for any autoantibody. The prevalence of aPL in the study group found to be statistically significant. Detection of aPL must be considered in women with previous pregnancies complicated by unexplained fetal wastage.
抗磷脂抗体（aPL）是一类针对带负电荷的磷脂 - 蛋白质复合物产生反应的多种自身抗体。具有临床意义的成员包括狼疮抗凝物（LA）、抗心磷脂抗体（aCL）以及导致梅毒血清学试验生物学假阳性（BFP）的反应素抗体。尽管在各种临床情况下均可检测到，但在育龄期女性不明原因的胎儿丢失中最为常见。对50名有两次或更多次不明原因妊娠丢失史的孕早期和孕中期孕妇进行了LA、aCL和反应素抗体检测。选取30名同一孕期且无任何胎儿丢失史的孕妇作为对照。研究组中9例（18%）检测到LA，12例（24%）检测到aCL。对照组所有自身抗体均为阴性。研究组中aPL的患病率具有统计学意义。对于既往妊娠合并不明原因胎儿丢失的女性，必须考虑检测aPL。
